Dermatology 1 > Psoriasis > Flashcards

Psoriasis Flashcards

(18 cards)

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1
Q

What is psoriasis?

A
  • Polygenic disorder and the phenotype is elicited by various triggers including trauma, illness and medications
  • chronic dz w/ intermittent remissions
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2
Q

age distribution of psoriasis

A
  • bimodal
  • 20-30
  • 50-60
  • mostly appears in 4th decade in women
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3
Q

genetic association w/ psoriasis

A

i. Associated with HLA-Cw6 and HLA-DR7
ii. Pustular associated with HLA-B27
iii. Guttate associated with HLA-B13 and HLA-B17
iv. Erythrodermic associated with HLA-B13 and B17

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4
Q

what disease has been linked w/ psoriasis?

A
  • Crohn’s

- locus on chrom. 16

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5
Q

triggers of psoriasis

A
  • sunburn, drug eruption, virus
  • strep infection
  • HIV
  • pregnancy –> pustular form
  • hypocalcemia
  • psychogenic stress
  • drugs
  • ETOH
  • smoking
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6
Q

what drugs can be triggers for psoriasis?

A
  • lithium
  • beta blockers
  • antimalarials
  • interferon
  • rapid taper of steroids
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7
Q

pathogenesis of psoriasis

A
  • t cell are driving factor

- activated t cell secrete cytokines which activate neutrophils in the epidermis

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8
Q

Auspitz sign

A

the pinpoint bleeding that occurs when plaque and underlying surface membrane is removed and is the clinical reflection of elongated vessels in the dermal papillae, in addition to thinning of the suprapapillary epidermis

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9
Q

What is the MC form of psoriasis?

A

chronic plaque dz

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10
Q

chronic plaque dz

A
  • fairly symmetric distribution of sharply defined erythematous scaly plaques
  • extensor surfaces***: elbows, knees, scalp, presacrum, hands and feet
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11
Q

how to rank severity of chronic plaque dz

A

-PASI: psoriasis area and severity index

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12
Q

What is the MC form of psoriasis in children?

A

Guttate psoriasis

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13
Q

Guttate psoriasis

A
  • more likely a hx of a preceding severe URI, esp. Strep inf**
  • good prognosis w/ spontaneous remission after tx of underlying infection
  • can sometimes progress to chronic plaque
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14
Q

palmoplantar pustular psoriasis

A
  • sterile pustules admixed w/ yellow-brown macules
  • chronic
  • commonly associated w/ inflammatory bone lesions
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15
Q

inverse psoriasis

A
  • in the axillae, inguinal creases, intergluteal cleft, inframammary and retroauricular folds
  • can be triggered by local fungal infections
  • characterized by shiny, pink to red, sharply demarcated plaques w/ minimal scale
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16
Q

nail psoriasis

Study These Flashcards
A
  • fingernails more common than toenails
  • effects the nail matrix and nailbed
  • seen as pits, leukonychia or oil spots
17
Q

psoriatic arthritis

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A
  • occurs mostly after experiencing skin lesions

- negative serologies but erosive change on XR

18
Q

what are the MC sites of psoriatic arthitis?

Study These Flashcards
A
  • DIPs and PIPs
  • “sausage digits”
  • can also have a shortening of digits = “pencil in cup”
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