Psych quick fire Flashcards

(85 cards)

1
Q

Management of less severe depression?

A

1st line - Guided self help (unless patient’s preference to start SSRI first)
2nd line - SSRI, group CBT, individual CBT, group exercise

SSRIs (fluoxetine, citalopram, sertraline, paroxetine, and escitalopram)

(take note that sertraline can increase the risk of suicidal ideation and self harm so weekly follow up for the first few months)

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2
Q

Management of more severe depression?

A

1st line - CBT + SSRI
2nd line - counselling, guided self help, group exercise, interpersonal psychotherapy

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3
Q

How long should antidepressants be taken for after remission of symptoms?

A

6 months

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4
Q

In a patient taking NSAIDS, if you prescribe an SSRI, what should you also prescribe and why?

A

PPI as there is an increased bleeding risk

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5
Q

Treatment for acute mania?

What is given for mood stabilisation?

(bipolar disorder)

A

STOP antidepressants

start antipsychotics e.g. risperidone, quetiapine, olanzapine

2nd line - alternate antipsychotic as mentioned above

3rd line - add lithium

(Electroconvulsive therapy is used for rapid short term treatment of a prolonged or severe manic episode when other treatments have not worked or the condition is life threatening and catatonia is present)

Lithium given for mood stabilisation (long term bipolar disorder) - if not suitable, atypical antipsychotic e.g. risperidone, quetiapine

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6
Q

What are people with bipolar disorder more at risk of?

A

2-3 times increased risk of:

Diabetes

Cardiovascular disease

COPD

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7
Q

2 biological symptoms of mania?

A

Increased energy

Reduced need for sleep - not associated with fatigue

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8
Q

2 cognitive symptoms of mania?

A

Reduced ability to concentrate

Elevated sense of self esteem

Racing thoughts/flight of ideas

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9
Q

2 psychotic symptoms of mania?

A

Tangential speech

Hallucinations

Delusions

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10
Q

Treatment for generalised anxiety disorder (include 1st and 2nd line pharmacological)

A

1st line - Education
2nd line - Low intensity interventions - guided self help
3rd line - High intensity interventions - CBT, SSRI
4th line - Specialist input

1st line - Sertraline
2nd line - Other SSRI (Paroxetine) or SNRI (duloxetine, venlafaxine)
3rd line - Pregabalin

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11
Q

Risk factors for generalised anxiety disorder (3) - including 1 medical condition

A

History of trauma

Family history

Substance use

Endocrine - HYPERTHYROIDISM phaechromocytoma, cushing’s,

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12
Q

Management of a panic attack?(1st and 2nd line pharmacological)

A

1) Recognition and diagnosis
2) Treatment in primary care: CBT, medication
3) Review and consider alternative treatment
4) Refer to specialist mental health services
5) Care in specialist mental health services

1st line - SSRI (Sertraline, fluoxetine, paroxetine)
2nd line - If doesn’t work after 3 months/if CI –> Imipramine/Clomipramine (TCA)

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13
Q

3 characteristics of ADHD?

A

Persistent hyperactivity, impulsivity and inattention

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14
Q

Management of ADHD? What do you need to monitor?

A

1st line - Psychoeducation + lifestyle (diet and exercise)
2nd line - CAMHS
3rd line - Drug treatment

  • Methylphenidate (monitor height and weight as it can cause stunted growth)
    2nd - Lisdexamfetamine
    (monitor ECG as some of them are cardiotoxic)
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15
Q

3 characteristics of someone with autism spectrum disorder

A
  • Repetitive behaviour (flapping of hands, eating same food every day)
  • Social impairment
  • Communication impairment
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16
Q

Screening tool for autism spectrum disorder

A

Childhood autism screening tool (CAST)

Childhood autism rating scale (CARS)

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17
Q

Management of autism spectrum disorder

A

Applied behavioural analysis
Early denver model - behavioural therapy
ASD preschool programme

(SSRI and antipsychotics can be given to reduce symptoms of repetitive behaviour and aggression)

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18
Q

What tool is used to classify the impairment of OCD?

A

Y-BOCS
Yale brown obsessive compulsive scale

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19
Q

Management of OCD?
Mild, moderate, severe

A

Mild - exposure and response prevention (CBT)
2nd line - SSRI (sertraline)

Moderate
- SSRI/TCA/more intensive CBT

Severe
- Referral to secondary care mental health team + CBT + SSRI

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20
Q

4 main symptoms of PTSD?

A

Avoidant

Negative alterations in mood

Alterations in arousal and reactivity

Mental intrusions

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21
Q

Treatment for PTSD?

A

If it’s mild and <1 month (acute stress disorder) - watchful waiting

Severe symptoms
- Trauma based CBT + Eye movement desensitisation and reprocessing (EMDR)
2nd line - Sertraline/venlafaxine/risperidone

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22
Q

Treatment for schizoaffective disorder?

A

Risperidone/quetiapine

CBT

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23
Q

2 risk factors for schizophrenia

A

Family history
Increased paternal age
Monozygotic twins
Black Carribean

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24
Q

3 prodromal symptoms (must be present for 6 months)

5 active phase symptoms (present for 1 month)

of schizophrenia

A

Prodromal sx
- Social withdrawal
- Reduced appetite
- Poor concentration
- Sleep difficulty
- Poor memory

Active phase
- Delusions of perception
- Passivity phenomenon
- Auditory hallucination
- Negative symptoms - Alogia (reduced speech and social withdrawal), anhedonia, avolition, affect flattening
- Thought disorder - withdrawal, insertion, broadcasting

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25
Treatment for schizophrenia?
Atypical antipsychotics (risperidone and quetiapine) + Offer CBT If other medications don't work - Clozapine
26
Side effects of clozapine?
Side effects: agranulocytosis, constipation, seizure
27
Factors associated with poor prognosis of schizophrenia? (3)
Strong family history Social withdrawal in the prodromal phase Low IQ Early age of onset Gradual onset of symptoms
28
4 key features of personality disorders (according to ICD 10)
PIDD Persistent - happen consistently over various situations Impairment - causes dysfunction in social life or work life Duration - characteristics are stable over time and not transient Distress - causes distress to either patient or people around
29
3 clusters of personality disorders and what do they encompass?
1) Odd and eccentric Paranoid - question loyalty of friends Schizoid - solo dolo Schizotypal - unusual behaviour, lack of close friends 2) Dramatic, emotional and erratic Borderline - recurrent suicidal actions, unstable relationships Antisocial - lack of remorse Narcissistic - chronic envy Histrionic - centre of attention, inappropriate sexual seduction 3) Anxious and fearful Dependent Avoidant Obsessive compulsive
30
Management of personality disorders
Psychological therapies e.g. dialetical behavioural therapy (talking therapy), CBT Psychotherapy (Drugs can be given to cluster A e.g haloperidol)
31
2 risks of using antipsychotics in the elderly?
Stroke and VTE
32
Common side effects of first gen antipsychotics? (5)
Extrapyramidal symptoms - PATAN - Parkinsonism (resting tremor, rigidity) - Akathisia (restlessness) - Tardive dyskinesia (involuntary movements of head, limbs trunk - CHEWING, grimacing of mouth and protruding tongue) - Acute dystonia - involuntary sustained muscle contractions (torticollis, oculogyric crisis) - Neuroleptic malignant syndrome - muscular rigidity, fever, sweating, (high CK) Hyperprolactinemia Antimuscarinic - dry mouth, burred vision, constipation Weight gain Neuroleptic malignant syndrome - pyrexia, hyperrigidity Diabetes Prolonged QT interval
33
Things to monitor when a person is on antipsychotics (3)
FBC - particularly looking out for agranulocytosis/neutropenia Lipids and weight - antipsychotics can cause weight gain Fasting blood glucose - can cause impaired glucose tolerance ECG and cardiovascular risk assessment - can cause QT prolongation or heart block Prolactin - can cause hyperprolactinemia Baseline BP - blocking of alpha 1 adrenergic receptors can cause orthostatic hypotension
34
3 medical conditions that can cause psychotic symptoms (not present with)
Temporal lobe epilsepsy Vitamin B12 deficiency Cushing's SLE MS Renal failure Huntington's disease
35
3 substances that can cause psychotic symptoms?
Cocaine Corticosteroids Dopamine agonists Hallucinogens Antidepressants
36
3 epidemiological and 3 clinical factors for suicide?
Epidemiology 19-34 males Divorced, widowed Unemployed/retired Living alone/social isolation Recent adverse life events e.g. relationship breakdown, personal/family health problems, financial difficulties Clinical Psychiatric illnesses particularly SCHIZOPHRENIA AND DEPRESSION Alcohol dependence Previous deliberate self harm Family history of depression, alcohol dependence or suicide
37
List 4 types of hallucinations
Auditory → Could be elementary e.g. buzzing or whistling sounds or complex e.g. voices heard in 1st, 2nd or 3rd person Visual → More commonly in people with brain disturbances e.g. dementia, delirium, epilepsy Somatic → Tactile (being touched, formication - insects crawling on skin associated with cocaine use or alcohol withdrawal), thermal, visceral (organs stretching or throbbing), kinaesthetic (false perception of limbs vibrating) Olfactory and gustatory (commonly occur together) → Make sure to rule out temporal lobe epilepsy and other organic brain diseases (dementia, delirium, tumours) Sleep related - Hypnopompic (hallucinations occurring as you’re waking up), Hypnagogic (hallucinations occurring as you’re going to sleep)
38
What is cataconia? List some examples
A state in which someone is awake but does not seem to respond to other people and their environment. (Can affect movement, speech and behaviour) - usually extreme muscular tone or rigidity. Catatonic rigidity - Maintaining a fixed position and resisting all attempts to be moved Catatonic posturing - Adopting and maintaining and unusual or bizarre position Catatonic negativism - Resistance to all instructions given (may even do the opposite of what is asked) Catatonic waxy flexibility - Can be moulded into a position that is maintained Catatonic stupor - Presentation of akinesis (lack of voluntary movement), mutism and extreme unresponsiveness in an otherwise alert patient.
39
List 4 different types of delusion
Persecutory delusion - Are you afraid that someone is trying to harm or poison you? Grandiose delusion - Do you believe you have special abilities or powers? (believing one is powerful) Delusions of reference - Have you ever felt that people on TV or on the radio are talking directly to you? (unrelated events/people are giving them a special message) Delusions of control (somatic) - Does it seem as though you are being controlled by an external force? Erotomanic delusion - Do you believe that someone is in love with you? (Nihilistic delusion - Do you believe you are dead or that the world has ended?)
40
Side effects of TCA? (5)
(multireceptor blocking effects like antipsychotics) Anticholinergic - dry mouth, constipation, urinary retention Alpha blockers - orthostatic hypotension Histamine blockage - weight gain Cardiotoxic - Arrhythmias, QT prolongation, heart block
41
Symptoms of alcohol withdrawal at 6-12 hours 36 hours 48 hours
6-12 hours - tremor, sweating, tachycardia anxiety 36 hours - peak incidence of seizures 48 hours - peak incidence of delirium tremens (coarse tremor, confusion, hallucination, delusions), fever
42
Treatment for alcohol withdrawal? Treatment in people with liver impairment? Anti craving medication for alcohol?
Benzodiazepine (long acting) e.g. First line - chlordiazepoxide 2nd line - diazepam Liver impairment - lorazepam Anti-craving - Acamprosate (safe with alcohol)
43
1 side effect of lorazepam
Anterograde amnesia
44
Symptoms of benzodiazepine withdrawal syndrome
PLAITS Perspiration Loss of appetite Anxiety Insomnia Irritability Tremor Tinnitus Seizures
45
Common drug interactions with SSRIs? (3)
NSAIDS - increased risk of GI bleeding (give PPI) MAO inhibitors - increased risk of serotonin syndrome (Phenelzine) Triptan - increased risk of serotonin syndrome Aspirin Warfarin/heparin (give mirtazapine rather than SSRI - but has side effect of increase in appetite)
46
Serotonin syndrome - Caused by? - Symptoms? Treatment?
Usually caused by 5 HT agonist drugs e.g. triptans, antiemetics like ondansetron. (or MAOI interactions) Sx - Clonus - Hyperreflexia - Hypertonoia - Tremors - Seizures - Hypertension, tachycardia - Confusion, anxiety - Sweating Tx: Cyproheptadine
47
How should SSRIs be stopped? Discontinuation symptoms? (3)
SSRI dose should be gradually reduced over a 4 week period Discontinuation sx GI sx: abdominal pain, cramping, diarrhoea, vomiting Sweating Difficulty sleeping Restlessness Paraesthesia
48
Which SSRI is most likely to cause QT prolongation and torsades de pointes?
Citalopram
49
Other than methadone, what is a suitable opioid replacement therapy? How is it administered?
Buprenorphine - sublingual tablet
50
Adverse effects of SSRIs? (3)
GI symptoms - vomiting and diarrhoea (early symptom which resolves with time) Hyponatremia Sweating Headache Insomnia Agitation (As they are not cardiotoxic -- they are the antidepressant of choice in cardiac disease)
51
What are some adverse effects of lithium therapy?
Nausea and vomiting Diarrhoea Fine tremor Nephrotoxicity- nephrogenic DI, CKD Hypothyroidism Weight gain Polydipsia, polyuria Idiopathic intracranial hypertension Hyperparathyroidism and resultant hypercalcemia (it can precipitate a benign leucocytosis - no concern - slightly raised WBC)
52
How often should you monitor lithium levels in a patient? What about with a change in dose? What level is considered toxic?
- After starting lithium - every week 12 hours post dose - Once established - every 3 months - After a change in dose - lithium levels should be taken a week later and every week after until levels stable Lithium levels >1.5 mmol/L is considered toxic
53
2 examples of how acute dystonia would present? How would you manage? What triggers it's onset?
Torticollis Oculogyric crisis (involuntary upward deviation of the eyes) (muscle spasm of the face, neck, tongue and back) Usually a side effect of a D2 receptor blocking drug e.g. antipsychotics. As dopamine is blocked, acetylcholine activity becomes excessive which causes sustained muscle contractions. (usually dopamine and acetylcholine in the basal ganglia are balanced) Treated with procyclidine (anticholinergic)
54
Difference in the side effects of atypical and typical antipsychotics
Typical - Extrapyramidal mainly Atypical - Metabolic syndromes mainly e.g. weight gain, diabetes
55
What drug increases mortality in dementia patients?
Antipsychotics (can heighten risk of cardiovascular events e.g stroke)
56
What can paroxetine and sertraline lead to if given in the first trimester?
Congenital heart defects
57
What is clanging?
Where speech is organised around the sound of words for example rhymes (rather than their meaning). E.g. I wrote the goat overload boat my float tote
58
What is neologism?
A newly made word which only has meaning to the person who created it but is unrecognised by/nonsensical to others.
59
What is perseveration?
A symptom where a person repeats words, phrases, thoughts or actions beyond the point where they are relevant or appropriate, often due to a failure of the brain to shift focus or stop a behaviour.
60
What are 2 factors that suggest a diagnosis of depression rather than dementia?
- Short history and rapid onset - Biological symptoms e.g. weight loss, sleep disturbance - Global memory loss (dementia usually causes recent memory loss)
61
What is a factitious disorder? (munchausen's syndrome)
The intentional production (feigning) of symptoms to assume a patient role
62
What is illness anxiety disorder? (hypochondriasis)
Persistent belief in the presence of an underlying serious DISEASE e.g. cancer (not symptom) - patient refuses to accept reassurance or negative test results (somatisation disorder is experiencing multiple SYMPTOMS)
63
What is section 2 under the mental health act 1983?
- Admission for assessment for up to 28 days (NOT renewable) - Psychiatrist + 1 doctor + Approved mental health professional (treatment can be given against a patient's wishes) (Designed for people in need of an assessment for a mental disorder, and due to their presentation and possible risks, it is felt it needs to take place in a hospital setting)
64
What is section 3 under the mental health act 1983?
- Admission for treatment for up to 6 months (can be renewed for a further 6 months then for periods of 1 year at a time) Approved mental health professional + 2 doctors (treatment can be given against a patient's wishes) (done following initial assessment under section 2 or if patient alr known by psychiatry services)
65
What is section 4 under the mental health act 1983?
An admission for assessment in cases of emergency --- valid for 72 hours (from time patient is admitted) (used when section 2 involves unacceptable delay)
66
What is section 5 (2) of the mental health act 1983?
A patient who is a voluntary patient in hospital can be legally detained by a doctor for 72 hours.
67
What is section 5 (4) of the mental health act 1983?
A patient who is a voluntary patient in hospital can be legally detained by a nurse for 6 hours.
68
Section 17a of the MHA 1983
Supervised community treatment Patients are given leave under this section --> conditions can be placed e.g. where they can go and whether it will be for a fixed period of time The clinician can revoke the leave and make the patient go back to the hospital. Or if the patient doesn't go back to the hospital at the end of their leave, they can be made to go back.
69
What is section 135 of MHA 1983?
Used by the police to enter a private property and remove a person that appears to have a mental health disorder and take them to a place of safety where they can be assessed.
70
What is section 136 of MHA 1983?
Used by the police to remove someone that appears to have a mental health disorder from a public place and take them to a place of safety where they can be assessed. This lasts for 24 hours.
71
What is capgras syndrome?
A condition characterised by the persistent belief that a family member or close friend is an imposter.
72
What is fregoli syndrome?
A delusional belief that a stranger is actually someone familiar in disguise. (believing different people are actually a single person in disguise) e.g. A woman in a psychiatric woman believes that all the nurses on the ward are actually her abusive brother in disguise.
73
What is metabolic syndrome? Risk factors?
A group of health problems that increase your risk of T2DM or conditions that affect the heart or blood vessels. This is linked to insulin resistance. Rf - Obesity - High saturated fat diet - Lack of exercise - Smoking - Alcohol - Hispanic or south asian background - Increased age
74
What antidepressant medication can help with insomnia?
Mirtazapine
75
Why are monoamine oxidase inhibitors (MAOI) used with caution? What is an early sign?
Due to their risk of interacting with different types of food and medication. (They irreversibly bind to monoamine oxidase A --> leading to a build up of amines which can cause hypertensive crisis) Interactions Dietary e.g cheese, soya bean, degraded protein (smoked fish, chicken liver) Drugs e.g. adrenaline, noradrenaline, L-dopa, dopamine, cocaine Early sign of throbbing headache
76
What is dysthymia?
A chronically depressed mood that is seldom sever enough to satisfy formal criteria for a depressive episode.
77
What is cyclothymia?
Characterised by alternating periods of mild elation and mild depression (mild bipolar disorder)
78
Take note that antihypertensives (especially methyldopa and beta blockers) and hypothyroidism are important causes of depression
79
What are the 5 markers/risks of metabolic syndrome?
1) Increased waist circumference 2) High blood pressure 3) High triglycerides 4) Low HDL cholesterol 5) High fasting blood glucose 3/5 need to be present to diagnose metabolic syndrome
80
What are some medications that can lead to metabolic syndrome?
Atypical antipsychotics (increase appetite) Corticosteroids (contribute to insulin resistance) Antihypertensives - diuretics and beta blockers can raise blood sugar levels (Treatment will be largely lifestyle - stop smoking, limit alcohol intake, exercise more, have a healthy balanced diet, Medication - diabetes drugs, ACE, statins)
81
gender dysphoria
82
Treatment for a) Acute dystonia b) Tardive dyskinesia
a) Procyclidine b) Tetrabenazine
83
What are some drugs that have adverse interactions with lithium?
NSAIDS Diuretics Ace inhibitors SSRI - paroxetine, fluoxetine Carbamazepine, phenytoin
84
What are 2 things that can cause clozapine blood level to rise?
Smoking cessation Alcohol bingeing
85
Definition of acute stress reaction. How does it present?
A transient disorder that develops in an individual without any apparent mental disorder in response to exceptional physical and mental stress that usually subsides within hours or days. Presentation Initial - disorientation, altered consciousness Followed by - withdrawal from surrounding situation or agitation. Signs of panic are present -tachycardia, sweating, flushing. (This can then develop into an acute stress disorder then PTSD)