Psychedelics / Cannabinoids

Question 1

Set

Answer 1

One’s mental expectations, past experiences, and attitude toward the current situation

Question 2

What is a common autonomic effect w/ psychedelics

Answer 2

Mydriasis

Question 3

What 2 receptors play a role in psychedelics?

Answer 3

Glutamate 2 and 5HT2A

Question 4

Ayahuasca

Answer 4

DMT

Question 5

Peyote

Answer 5

Mescaline

Question 6

Chemicals in mushrooms

Answer 6

•Psilocybin is converted to psilocin, which is the active ingredient.

Question 7

MDMA
Use / effects
Mechanism
Adverse rxns

Answer 7

• Use – May be useful for PTSD and terminal cancer. Causes feelings of closeness, increased communication, love, mental / physical wellbeing, reduction in fear associated w/ trauma.
• Mechanism – 5HT, DA and NE releaser and uptake transporter
• Adverse rxns
• High dose can produce 5-HT syndrome, hyperthermia
• CV: ↑ HR, ↑ BP
• CNS: dizziness (40%), restlessness (39%), anorexia (70%), insomnia (17%), tremor (14%), bruxism (63%), nystagmus (23%)
• Precautions – Mental illness: psychosis, mania, paranoia

Question 8

THC
Use
Mechanism
Adverse rxns

Answer 8

• Use – FDA approved for antiemetic and appetite stimulating effects. Others include analgesic (especially neuropathic pain), antispastic, and antiglaucoma effects.
• Mechanism – acts on CB1 (central) and CB2 (peripheral) receptors. Lower IOP by 25% in pxs w/ glaucoma.
• Adverse rxns – decreased BP, increased HR

Question 9

Nabilone
Use
Mechanism

Answer 9

• Use – antiemetic (cancer pxs) and analgesic effects

* Mechanism – synthetic cannabinoid agonist at CB1 receptor. Reduces proemetic signaling in the vomiting center.