what is PUD?
ulcerations > 5mm in diameter of the stomach or duodenum that penetrare through to the muscularis
stomach- gastric ulcers
duodenum- duodenal ulcers
what kind of ulcer is more common?
gastricduodenal
what age does this occur in?
ANY AGE
what are the 2 huge common causes of peptic ulcers?
disruption of normal mucosal defenses and repair
1. h. pylori infxn -> 80-90% duodenal ulcers, 70-80% gastric ulcers
2. use of NSAIDS and ASA -> >50% peptic ulcers (gastric>duoddenal)
what are the RF for peptic ulcers?
NSAID/ASA use
h. pylori infxn
cigarette smoking
alcohol
stress (severe illness related, psychologic)
diet (food storage)
genetic predisposition