Pulm. Pharm

Question 1

• Drug of choice for long term, persistent
• MOA: Inhibit cytokine synthesis–>inflamm. response
• Low SE

Answer 1

Inhaled Corticosteroids

Question 2

• MOA; Anti-inflamm.

- Asthma exacerbations

Answer 2

Systemic steroids

Question 3

• MOA: Inhibits mast cells degranulation. Used as prophylaxis
• Min S/e

Answer 3

Mast Cell Stabilizer

Question 4

• 1st line treatment for acute attack
• MOA: Bronchodilator
• S/E: Beta-1 cross reactivity–>tachycardia, muscle tremors, CNS Stimulation
• Does nothing for inflammation

Answer 4

Short Acting Beta(2) Agonist

Question 5

• Bronchodilator

- Good for nocturnal Asthma symptoms

Answer 5

Long Acting Beta(2) Agonist

Question 6

Central bronchodilator (inhibits vagal-mediated bronchoconstriction), inhibits nasal mucosal secretions, + synergistic interaction with B2 Agonists
-S/E thirst, vision changes, dry mouth

Answer 6

Anticholinergics

Question 7

-Relieves airflow restrictions

Answer 7

Phosphodiesterase Inhibitors

Question 8

• Blocks leukotriene-mediated neutrophil migration, capillary permeablitly, smooth muscle contraction.
• Never mono therapy
• Moderate to severe asthma that doesn’t respond well to other txs

Answer 8

Leukotriene Receptor Antagonists