Canine infectious respiratory disease (CIRD) complex causes
Bacterial
* Bordetella bronchiseptica
* Streptococcus zooepidemicus
* Mycoplasma cynos
Viral
* Canine parainfluenza
* Canine respiratory coronavirus
* Canine influenza virus
* Also distemper, adenovirus 2, herpesvirus 1, less
Pulmonary lesions with sepsis
Edema and fibrin
Hypercellularity of alveolar septa (increased PIMs)
Thrombosis of capillaries
Breed that gets syndrome of interstitial pulmonary fibrosis; age?
West Highland White Terriers, 6-12 years
What bacteria secrete RTX toxins?
Actinobacillus pleuropneumoniae- Apx I, II, III
Mannheimia haemolytica- leukotoxin
E.coli- hemolysin
Causes of primary lung disease in swine
PRRSV
Mycoplasma hyopneumoniae
Influenza A
PCV-2
Opportunistic pathogens in the lungs
Pasteurella multocida
Streptococcus suis
Bordetella bronchiseptica
Haemophilus parasuis
Features of mycobacteria
Nonmotile, nonspore-forming, pleomorphic coccobacilli
Acid fast
High lipid content
Hydrophobic layer of mycolic acids- environmental and antimicrobial resistance
Tuberculoproteins
Purified protein derivatives- intradermal skin testing
Survive within macrophages
What cytokines promote tuberculoid granuloma formation?
TNF-alpha and IFN-gamma
What factor confers virulence to mycoplasma mycoides SCT; location and mechanism
Galactan; mucus capsule, induces necrosis, thrombosis, and inflammation
Only lungworm of cattle; infectious stage?
Dictyocaulus viviparus; L3
lentiviruses infect what cell? where does replication occur?
Choroid plexus, mammary epithelium, fibroblasts, endothelial cells, monocytes; ONLY IN MACROPHAGES
What makes small ruminant lentivirus different from all other lentiviruses?
NO IMMUNOSUPPRESSION
Nasal mite of dogs
Pneumonyssoides caninum
Eucoleus aerophilus lives where?
trachea and bronchi of dogs (trichurid)
Oslerus osleri lives where?
Trachea and bronchi of dogs (metastrongyle)
Crenosoma vulpis lives where?
Bronchioles and small bronchi of dogs (metastrongyle)
Angiostrongylus vasorum lives where?
Pulmonary arteries, with eggs and larvae in lungs (Metastrongyle)
Filaroides hirthi lives where?
Alveoli and bronchioles of dogs (Filaroididae), subpleural lesions
Andersonstrongylus milksi lives where?
Adults in bronchioles and alveoli (metastrongyle)
What are associated lesions with calicivirus in a cat?
Oral ulcers (ulcerative stomatitis)
Skin lesions (if virulent systemic type)
What is the lungworm of cats?
Aelurostrongylus abstrusus (Metastrongyle)
Only trematode that infects the lungs? Who gets it?
Paragonimus kellicotti; fish eating carnivores (cats)
