Definition of PUO
High fever for at least 3 weeks
Not necessarily due to infection (fevers also caused by neoplasms and CT diseases)
Definition of hospital aquired PUO
temp >38.3, several times (doesnt need to be 3 weeks), hospitalised
Definition of neutropenia pUO
temp >38.3 several occasions
Neutrophils <500
HIV associated PUO definition
temp >38.3
HIV positive
Minimum essential investigations for PUO
FULL HISTORY
3x blood culture sets
Blood tests (FBC, ESR, CRP, LFTs, bone profile etc)
HIV test!
Culture urine and sputum
CHEST X RAY!
Management of PUO?
Watch and wait if patietn is stable
Empirical abx in unstable patients