Quest 3 Flashcards

(51 cards)

1
Q

What is Transmission Genetics?

A

mechanism by which genes are passed on from parents to offspring

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2
Q

What are the two points of Mendel’s Law?

A
  1. Segregation - Each individual possesses two alleles (versions of a gene) for a trait, but only one is passed to offspring.
  2. Independent Assortment - genes for different traits are inherited independently of one another. Linked or unlinked genes have different and important consequences with natural selection.
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3
Q

What are Genes?

A

the functional and physical unit of heredity (instruction manuals for your body).

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4
Q

What are Exons?

A

coding sequences that are expressed

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5
Q

What are Introns?

A
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6
Q

What is Splicing and alternate splicing?

A

Splicing is the cell’s process of cutting out non-coding regions (introns) from pre-mRNA and pasting together the coding segments (exons) to create mature mRNA

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7
Q

What is Particulate Inheritance?

A

Mendelian theory that genetic traits are transmitted from parents to offspring via discrete, separate units that maintain their identity across generations rather than blending together.

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8
Q

What is Blending Inheritance?

A

offspring inherit traits as a uniform blend or average of their parents’ characteristics.
- Mendel disproved this by cross-breeding different colored flowers (white and purple) where he observed that the F1 generation did not show blended traits (blended color i.e. lilac), and hidden traits reappeared in the F2 generation.

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9
Q

What is DNA made of?

A

Bases (Adenine, Thymine, Guanine, Cytosine)

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10
Q

DNA is more stable than…

A

RNA

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11
Q

When DNA is packed, it’s called…?

A

Chromosomes

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12
Q

DNA is found in the…

A

Nucleus

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13
Q

An organism with one copy of DNA is called…

A

Haploid

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14
Q

DNA is also found in…

A

Mitochondria (also chloroplasts)

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15
Q

Where did DNA come from?

A

Endosymbiosis

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16
Q

What is Transcription?

A

copying a specific segment of DNA into a complementary RNA molecule.

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17
Q

What is a Promoter?

A

It initiates transcription

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18
Q

What is RNA Polymerase?

A

catalyzes transcription (binds and unwinds the double helix in DNA)

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19
Q

What are Proteins?

A

building blocks for body tissues

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20
Q

What is mRNA?

A

(messenger RNA); carries genetic information from DNA in the cell nucleus to the cytoplasm

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21
Q

What are Amino Acids?

A

Build proteins

22
Q

What is tRNA?

A

(transfer RNA); transfers genetic code

23
Q

What is Mutation?

A

a permanent, heritable change in the DNA sequence of an organism

24
Q

What is rRNA?

A

(ribosomal RNA); folds and makes ribosomes

25
What are Codons?
bases that start/stop translation
26
What is microRNA?
prevents the production of certain proteins by binding and destroying them.
27
What is Translation?
converts genetic instructions (mRNA) into functional proteins.
28
What is Genetic Code?
set of rules used by living cells to translate information encoded within genetic material (DNA or mRNA) into proteins.
29
What is Codon Bias?
Different groups favor certain codons more than others.
30
What is Redundancy?
All amino acids have codons to code for specifically
31
What is Epigenetic inheritance?
heritable mechanisms that alter gene expression without changes to the DNA. Typically on the cellular level, some cases found across meiosis to the next generation.
32
What is Methylation?
often stops transcription by blocking promoters and RNA polymerase
33
What are the four sources of variation?
1. Recombination (within pop.) 2. Mutation (within pop.) 3. Migration (outside population) 4. Lateral Gene transfer (outside population; usually in bacteria)
34
Mutation: What types are there?
Nonsense (genetic change where a single nucleotide creates a stop codon), synonymous (alters the sequence of a gene but does not change the amino acid; silent), nonsynonomous (changes the amino acid sequence; could be damaging)
35
Frequencies of Discrete Traits
the proportion or percentage of individuals in a population that exhibit a specific, distinct phenotype controlled by one or a few genetic loci - (Ex: aloe spiral direction)
36
HWE Hardy Weinberg Equilibrium
- This Null Model tells us what happens to a population if none of the evolutionary processes are at work (i.e. selection) - Hardy and separately Weinberg (and William Castle of Ohio in 1903), wanted to know what happens to alleles passed from parent to offspring if only transmission genetics are in play.
37
Selection acts on Individuals, changes populations
1. Individual-level thinking: What gametes and offspring are produced, in what frequencies from a given pair of parents? 2. Population-level thinking: How doe the characteristics of the population change over time as the result of evolutionary processes?
38
HWE Conclusions
1. Frequencies of alleles p and q do not change over time without eco processes. Also used as A1 and A2. 2. Given allele frequencies (freq. of p and q) and random mating we can predict the equilibrium genotype frequencies. p^2 2pq q^2 or A1A1, A1A2, A2A2 the Hardy-Weinberg equilibrium freqs. 3. If there are no evolutionary processes at work then a pop. not in HWE will go to HWE in one generation
39
5 Assumptions of HWE
1. No Natural Selection - there is no selection acting on the trait or trusts in question 2. Random mating (no sexual selection) - No assortative mating, all mating is random with respect the the trait in question 3. No Mutation - no mutation at the locus or trait 4. No migration AKA Gene Flow 5. Population is infinite, so no genetic drift
40
Selection coefficient
41
What is Frequency Independent? (know examples)
The fitness associated with a trait is not directly dependent on the frequency Ex: Directional Selection (the rock pocket mouse)
42
What is Dependent Selection? (know examples)
43
Frequency Independent Selection - Directional Stabilizing, Disruptive
1. Directional selection - For one extreme against the other 2. Stabilizing selection - for the middle and against both extremes 3. Disruptive selection - for both extremes against the middle
44
1. What is Overdominance (Heterozygous Advantage)? 2. What is Balanced polymorphism (Stable equilibrium, balanced selection)?
1. is a genetic condition where an individual with two different versions of a gene (heterozygote, e.g., π΄π‘Ž) is more fit, stronger, or better adapted than individuals with two identical versions (homozygotes, e.g., 𝐴𝐴 or π‘Žπ‘Ž) - Ex: if you have sickle cell, you're immune to malaria 2. an evolutionary mechanism where natural selection maintains two or more different alleles (gene variants) in a population at stable frequencies, preventing any single allele from being eliminated
45
What is Underdominance (Heterozygous Disadvantage)?
- Worst case scenario - is a genetic phenomenon where heterozygous individuals (π΄π‘Ž) have lower fitness (survival or reproductive success) than both homozygous genotypes (𝐴𝐴 and π‘Žπ‘Ž).
46
What is Frequency Dependent Selection (Positive and Negative)?
Frequency dependent selection is when the cost or benefit associated with the trait changes depending on its frequency in the population. - Positive - fitness of the trait increases as the frequency increases - Negative - when the fitness associated with the trait decreases as the frequency increases
47
Viability selection vs. Fecundity selection
Viability selection improves an organism's probability of surviving from zygote to adult, while fecundity selection increases the rate of reproduction and offspring production.
48
Mutation - selection balance
When the rate of deleterious allele elimination = rate of new allele creation via mutation q=sqrt (u/s)
49
What is Non-random mating, Assortative and Disassortative Mating, Inbreeding, and Inbreeding Depression?
Non-random mating: individuals selecting partners based on specific phenotypes, proximity, or genetic relatedness. Assortative mating: individuals with similar phenotypes (observable traits) or backgrounds (e.g., education, ethnicity) pair together more frequently than by chance. Disassortative mating: individuals with dissimilar phenotypes or genotypes mate more frequently than expected by chance. Causes excess of heterozygotes. Inbreeding: causes genotype frequencies to change in favor of homozygotes while the allele frequencies do not change at all. Inbreeding Depression: the result of selfing and reproduction with genetic relatives. It happens as a consequence of increasing homozygosity.
50
Identical by Descent
51
Migration - Effects of Pop get Processes on Variation
1. It causes gene pools between populations to be more similar 2. Adds genetic variation to populations