RA

Question 1

methotrexate dosing

Answer 1

is weekly not daily
daily is fatal
max is 20mg/week

Question 2

methotrexate SE

Answer 2

M-mucositosis,myleosupression
E
T
H-hepatoxicity
O- phOtosensitivity
T
R-Renal (give bicarb to keep urine alkaline), Rash
E
X-Preg. Cat. X, Chest X-ray(pulmonary fibrosis)

Question 3

avoid which antibiotic with methotrexate

Answer 3

bactrim, bc increase risk of mtx toxicity

Question 4

methotrexate is

Answer 4

an antimetabolite
and 
s phase toxic
and 
folic acid structural analog

Question 5

washout procedure for leflunomide (arava)

Answer 5

cholestyramine 8 grams tid for 11 days

Question 6

leflunomide, mtx, and azathioprine are

Answer 6

not to be used in pregnancy

Question 7

allopurinol and febuxostat are

Answer 7

xanathine oxidase inhibitors

must decrease dose of azathioprine