RA (TsDMARDS)

Question 1

what are the target-specific non-biologic DMARDs?

Answer 1

1. tofacitinib
2. upadacitinib
3. baricitinib

Question 2

What is the MOA of the tsDMARDS (non biologics)

Answer 2

Janus associated kinase inhibitor

Question 3

what is the onset of Tofacitinib?

Answer 3

2 weeks

Question 4

what are the ADRs of Tofacitinib?

Answer 4

1. infection
2. diarrhea
3. nausea
4. headache

Question 5

what are the warnings of Tofacitinib?

Answer 5

1. bone marrow suppression
2. decreased HR
3. GI perforation
4. hepatotoxic

Question 6

what to monitor when taking Tofacitinib?

Answer 6

1. CBC
2. LFTs
3. sCr
4. lipids
5. hepatitis
6. TB

Question 7

what is the BBW of Tofacitinib? (Oral drug)

Answer 7

1. serious infection
2. lymphoma and other malignancies
3. thrombosis
4. increased all cause mortality
5. TB

Question 8

what are the ADRs of Upadacitinib?

Answer 8

1. URTI
2. neutropenia
3. nausea
4. thrombosis
5. increased lipids

Question 9

what is the dose of Upadacitinib? PO

Answer 9

Daily

Question 10

What to monitor for Upadacitinib?

Answer 10

1. CBC
2. LFT
3. Lipids

Question 11

What are the BBW of Upadacitinib?

Answer 11

1. Serious infection
2. Malignancies
3. Thrombosis

Question 12

What are the ADRS of Baricitinib

Answer 12

1. URTI
2. Nausea
3. Thrombosis
4. Increased LFTs
5. Lipids

Question 13

What to monitor for Baricitinib

Answer 13

1. CBC
2. LFTs
3. Lipids

Question 14

What are the BBW of Baricitinib

Answer 14

1. Serious infections
2. Malignancies
3. Thrombosis

Question 15

can a patient take both Methotrexate and tofacitinib?

Answer 15

Yes

Question 16

can a patient take both Tofacitinib and baracitinib?

Answer 16

No
*no tsDMARDS (biologics) together

Question 17

can a patient take Methotrexate, leflunomide, sulfasalazine, hydroxychloroquine and tofacitinib?

Answer 17

Yes

Question 18

can 2 bDMARDs be used together?

Answer 18

No

Question 19

can a JAK inhibitor and bDMARD be used together?

Answer 19

No