Definition and Equation for Tpot
Cell doubling time without any cell loss
Tpot = Tc / GF
Definition and equation for cell loss factor
Ratio of rate of cell loss over rate of new cell production
Cell loss factor = 1 - (Tpot/VDT)
VDT: volume doubling time
Define growth fraction
The number of cells actively replicating divided by the total number of cells in the tumour
Define tumour heterogeneity
Existence of distinct subpopulations of cells with different genetic, phenotypic, or molecular profiles within a single tumour or between tumours of the same type
Define tumour stem cell
A small subset of cells within a tumour that posses the unique ability to self-renew, drive tumorigenesis, and differentiate into the heterogeneous cells comprising the bulk of the tumour.
Define the law of Bergonie and Tribondeau
The radio sensitivity of a tissue is directly proportional to the reproductive activity and inversely proportional to the degree of differentiation
what are the 4 steps of RNA transcription
initiation
elongation
termination
post-transcription modification
what are the 4 steps of RNA translation
activation
initiation
elongation
termination
marker for cell senescence
SA-beta-Gal
define doubling dose
radiation dose required to double the number of spontaneous genetic mutations in a given population of cells
define latency
time between injury occurring and the effects of the injury expressing themselves as disease. (for late side effects it’s time between completion of RT and clinical manifestation of the particular effect)
define functional subunit
largest unit of cells capable of being regenerated from a surviving clonogenic cell without loss of the specified function
