Random Flashcards by Dr. Doy Zoy

erythema annulare centrifugum

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erythema annulare centrifugum

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Diagnosis
This finding may be seen in what syndromes or conditions?

Cafe Au Lait Spots
neurofibromatosis type 1 (NF1), familial multiple CALMs (Legius syndrome), McCune-Albright syndrome, Bloom syndrome, Watson syndrome, and Silver-Russel syndrome

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Shagreen patch

Tuberous sclerosis

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Acne keloidalis nuchae (syn. folliculitis keloidalis nuchae)

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Acrodermatitis continua of Hallopeau (syn. acropustulosis)

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Acrodermatitis enteropathica

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Acropustulosis of infancy

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Lichen Amyloidosis

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Macular Amyloidosis

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Anetoderma

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Anetoderma

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Angiofibromas

Tuberous sclerosis

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Angiokeratoma

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Anthrax

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hidrocystoma

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Hidrocystoma

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Atrophoderma vermiculatam

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Atrophoderma of Pasini and Pierini

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Becker nevus

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Beau lines

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Behçet syndrome

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Blue nevus

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Bowenoid papulosis

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Cafe-au-lait patch Neurofibromatosis type 1

Calciphylaxis

Central centrifugal cicatricial alopecia

Chancroid

Cherry angioma (syn. Campbell de Morgan spots)

Chickenpox (syn. varicella)

Chondrodermatitis nodularis helicis

Chronic bullous disease of childhood

Condylomata acuminata Hov 6 & 11

Confluent and reticulated papillomatosis

Congenital dermal melanocytosis (syn. Mongolian spots)

Congenital melanocytic nevus

Cryptococcosis

Cutaneous horn

Cutaneous larva migrans Ancylostoma braziliense Ancylostoma caninum

Cutis laxa

1. Diagnosis 2. Associated syndromes 3. gene mutation

1. Cylindroma 2. Brooke-Spiegler syndrome, Multiple familial trichoepitheliomas 3. CYLD1

Darier disease ATP2A2 MUTATION Autosomal dominant

Dermatitis herpetiformis

Dermatofibrosarcoma protuberans

Dermatomyositis

Dermatosis papulosa nigra

Dermoid cyst

Discoid lupus erythematosus (chronic cutaneous lupus erythematosus)

Dissecting cellulitis

Ecthyma (including ecthyma gangrenosum)

Eczema coxsackium Hand foot mouth disease Cocksackie virus a6 & a16

Eczema: asteatotic eczema (syn. xerotic eczema, eczema craquele)

En coup de sabre Linear Morphea

1. Diagnosis 2. Pattern of inheritance 3. gene mutation

1. Ephelides (syn. freckles) 2. autosomal dominant 3. MCR-1 gene

Epidermodysplasia verruciformis ## Footnote * rare, heritable skin disorder with a mild underlying primary immunodeficiency * Widespread flaky, scaly, or flat warty lesions are seen on the face, hands, and forearms and other sun-exposed sites * There is often erythema, hyperpigmentation, or more rarely hypopigmentation of lesions, and there can be confusion with pityriasis versicolor and plane warts * In early adult life, actinic keratoses, Bowen disease, and invasive squamous cell carcinoma (SCC) can develop at affected sites

Epidermolysis bullosa acquisita

Eruptive xanthoma

Erysipelas

Erysipeloid

Erythema (chronicum) migrans Lyme Disease

Erythema ab igne

Erythema annulare centrifugum

Erythema dyschromicum perstans (syn. ashy dermatosis)

Erythema elevatum diutinum

1. Diagnosis 2. What is the most commonly associated malignancy?

1. Erythema gyratum repens 2. Lung CA

Erythema infectiosum (syn. fifth disease; slapped cheek syndrome) Parvob19

1. Diagnosis 2. Associated topical medications 3. Associated oral medication

1. Exogenous ochronosis 2. Hydroquinone > 4%, phenol, resorcinol 3. Quinine (antimalarial)

Extramammary Paget disease of skin

Folliculitis barbae

Folliculitis decalvans

Fordyce spots (syn. Fordyce’s granules)

Fox-Fordyce disease (syn. apocrine miliaria)

Frontal fibrosing alopecia

Gianotti-Crosti syndrome (syn. papular acrodermatitis of childhood)

Granuloma faciale

Granuloma inguinale (syn. Donovanosis)

Grover disease (syn. transient acantholytic dermatosis)

Hailey-Hailey disease (syn. familial benign chronic pemphigus) Atp2C1

Hand, foot and mouth disease

Henoch-Schönlein purpura

Histoplasmosis

Nevus of hori

Hori's Nevus

Ichthyosis vulgaris

Idiopathic guttate hypomelanosis

Incontinentia pigmenti

1. Diagnosis 2. Stain that can highlight cells 3. cells seen in mature lesions

1. Juvenile xanthogranuloma 2. stabilin-1, CD163, CD11b, CD11c, CD36, CD68, factor XIIIa, and vimentin 3. foam cells, Touton giant cells, and foreign-body giant cells

Kawasaki disease

Kaposi’s sarcoma (syn. Kaposi’s haemorrhagic sarcoma)

Inflammatory linear verrucous epidermal nevus

1. Diagnosis 2. Associated syndromes 3. This may be a side effect of what medication?

1. Keratoacanthoma 2. Muir-Torre Syndrome/ Ferguson-Smith Syndrome 3. BRAF inhibitors (sorafinib, vemurafenib, dabrafenib)

Keratolysis exfoliativa

Keratosis rubra pilaris faciei atrophicans (syn. ulerythema ophryogenes)

Kerion Tinea Capitis

Koilonychia

Lamellar ichthyosis

Lichen aureus

Lichen nitidus

Lichen planopilaris

Lichen planus pigmentosus

Lichen spinulosus (syn. keratosis spinulosa)

Lichen striatus

Lupus pernio

Lupus vulgaris

Lymphogranuloma venerum

Majocchi purpura (purpura annularis telangiectodes)

Measles

Median nail dystrophy

Merkel cell carcinoma

Milia

Mucocele (syn. mucous extravasation cyst; mucous retention cyst; ranula)

Nevus anemicus

Naevus depigmentosus (syn. achromic naevus)

1. Diagnosis 2. Area of predilection 3. Treatment of choice

1. Nevus of Ota 2. Unilateral pigmentation in the area of the first and second branches of the trigeminal nerve 3. Laser surgery is the treatment of choice with quality-switched (QS) lasers including **quality-switched ruby laser, QS alexandrite laser and QS neodymium:yttriumaluminum-garnet (Nd:YAG) laser**

Nevus of Ito

Nevus sebaceus of Jadassohn (syn. sebaceous naevus; organoid naevus)

Nevus spilus

Pachyonychia congenita

Paget’s disease of the nipple

Palmoplantar keratoderma

Paraneoplastic pemphigus

Pearly penile papules

Pemphigoid gestationis (pemphigoid of pregnancy)

Pemphigus foliaceus

Pemphigus vulgaris

Perforating dermatoses

1. Diagnosis 2. gene mutation 3. pattern of inheritance

1. Peutz-Jeghers syndrome 2. STK11 3. Autosomal dominant

Periungual fibromas

Phrynoderma

Piebaldism

Pigmented spindle cell naevus of Reed

Pincer nail deformity

Pitted keratolysis

Pityriasis amiantacea

Pityriasis lichenoides

Pityriasis rubra pilaris

Poikiloderma of Civatte

Pityriasis versicolor

Pilar cyst (syn. trichilemmal cyst)

Polymorphic eruption of pregnancy (syn. pruritic urticarial papules and plaques of pregnancy)

Porokeratosis

Porphyria

Port-wine stain (syn. naevus flammeus)

Pseudopelade of Brocq

Pseudoxanthoma elasticum (syn. Gronblad-Strandberg syndrome)

Pseudomonal nail infection

Pyoderma gangrenosum

Relapsing polychondritis

Rosacea

Scarlet fever (syn. scarlatina) Streptococcus pyogenes (GAS) Streptococcal pyrogenic exotoxin A, b, C

Schamberg disease

Schwannoma (syn. neurilemmoma)

Scleromyxoedema

Scrofuloderma

Sebaceous gland hyperplasia

Shagreen patch Tuberous sclerosis

Solar elastosis (syn. actinic elastosis)

Solar lentigo

Speckled lentiginous naevus (syn. naevus spilus)

Spitz naevus (including pigmented spindle cell naevus of Reed)

Staphylococcal Scalded Skin syndrome (syn. Ritter disease; staphylococcal epidermal necrolysis) Exfoliative toxin Desmoglein 1

Steatocystoma multiplex

1. diagnosis if >30%BSA? 2. diagnosis if <10%? 3. what is the associated HLA if caused by allopurinol? 4. what is the associated HLA if caused by carbamazepine?

1. Toxic Epidermal Necrolysis 2. Stevens-Johnson Syndrome 3. HLA-B*5801 4. HLA-B*1502

Subacute cutaneous lupus erythematosus

Subcorneal pustular dermatosis (syn. Sneddon-Wilkinson disease)

Subungual haematoma

Sweet syndrome (syn. acute febrile neutrophilic dermatosis; Gomm-Button disease)

Sycosis barbae

Syphilis

Syringocystadenoma papilliferum

1. diagnosis 2. associated syndrome

1. syringoma 2. down syndrome

Systemic lupus erythematosus

Systemic sclerosis

Talon noir

Telangiectasia macularis eruptiva perstans

Terry nails Severe liver disease

Terra firma-forme dermatosis

tendinous xanthoma

Tinea capitis

Tinea faciei (face) and barbae (beard)

1. Diagnosis 2. Etiologic agent

tinea imbricata Caused by Trichophyton concentricum

Toxic epidermal necrolysis

1. diagnosis 2. syndromes associated

1. trichoepithelioma 2. Brooke-Spiegler, Multiple familial trichoepitheliomas, Rombo, Bazex-Dupré-Christol

trichoepithelioma

trichofolliculoma

Tripe palms (syn. acanthosis palmaris, acquired pachydermatoglyphia)

Tuberous sclerosis

Tuberous xanthoma

Urticaria pigmentosa

Varicella (syn. chickenpox)

Venous lake

Xanthelasma

Xanthoma disseminatum

1. Identify. 2. Describe the lesions 3. What condition is this seen?

1. Herpes Iris of Bateman 2. Large lesions with a central bulla and a marginal ring of vesicles 3. Erythema Multiforme

Erythema Elevatum Diutinum

Lichen Striatus

Granuloma Faciale

Telangiectasia macularis eruptiva perstans.

Telangiectasia macularis eruptiva perstans (TMEP)

Grover Disease

Darier Disease

Folliculitis decalvans.

Stucco keratoses present as multiple small 1- to 3-mm white to tan keratotic papules with predilection for the distal extremities, particularly the lower legs.

1. Diagnosis 2. Associated HPV types 3. Associated mutations

1. EPIDERMODYSPLASIA VERRUCIFORMIS 2. HPV types 5 and 8 3. loss of function mutations of EVER1 and EVER2 genes - inherited skin condition with a high local susceptibility to infection with human papillomavirus (HPV), most commonly with HPV types 5 and 8. - widespread, flat, wart-like papules and plaques, or hypopigmented scaly patches in childhood. - Loss-of-function mutations of the genes EVER1 and EVER2 are associated with EV.

mode of inheritance of Epidermodysplasia verruciformis (EV)

autosomal recessive or X-chromosomal recessive

Identify this type of scale. What condition is this seen?

Ichthyosis Linearis Circumflexa - polycyclic, serpiginous, migratory, DOUBLE-EDGED SCALE at the margins of erythematous plaques Seen in NETHERTON SYNDROME

Identify the type of scale. What condition is this seen?

Ichthyosis Linearis Circumflexa - polycyclic, serpiginous, migratory, DOUBLE-EDGED SCALE at the margins of erythematous plaques Seen in NETHERTON SYNDROME

Linear and whorled nevoid hypermelanosis

* Congenital diffuse reticular hyperpigmentation with nail atrophy and leukoplakia. * Manifests in the first few years of life. * Extracutaneous manifestations are bone marrow failure and malignancies.

DYSKERATOSIS CONGENITA ## Footnote * Reticulate skin pigmentation especially on the neck and chest, nail atrophy in fingernails and toenails, and leukoplakia are seen in those with DKC. * Extracutaneous manifestations include bone marrow failure (in more than 80% of cases) and malignancy in the second and third decades of life.

1. diagnosis 2. associated viral infections and conditions

1. ERUPTIVE PSEUDOANGIOMATOSIS 2. Echovirus, Adenovirus, CMV, arthropod bites, and immunocompromised states ## Footnote * small, 2- to 4-mm, red papules that resembled **angiomas** on the face and extremities * The papules** blanched on pressure **and were surrounded by a **small, 1- to 2-mm, halo. ** * The eruption was short lived and typically resolved within 10 days * Patients often had associated **fever, malaise, headache, diarrhea, and respiratory complaints.**

1. Diagnosis 2. Stain to highlight cells 3. characteristic finding ultrastructurally

1. Benign cephalic histiocytosis 2. CD68 3. ultrastructural presence of worm-like bodies

diagnosis?

Angiolymphoid hyperplasia with eosinophilia (ALHE)

1. Diagnosis of this paraneoplastic syndrome 2. What is the associated malignancy?

1. Necrolytic Migratory Erythema 2. Glucagonoma

1. Diagnosis 2. most commonly associated malignancy

1. Pityriasis Rotunda 2. hepatocellular carcinoma ## Footnote * Skin manifestations are characteristic, consisting of **perfectly round or oval, asymptomatic, well-defined, hypopigmented or hyperpigmented ichthyosiform scaly patches **that appear on the trunk and proximal extremities * **Type 1 pityriasis rotunda** is associated with underlying malignant or systemic disease and presents with **<30 skin lesions**; more common in black and East Asian patients

. Diagnosis of this paraneoplastic syndrome 2. Most common associated malignancy

1. Acrokeratosis paraneoplastica of Bazex 2. Upper aerodigestive tract malignancy ## Footnote * The characteristic cutaneous findings are symmetrical erythematous to violaceous scaly patches or plaques over the acral extremities, ears, and bridge of the nose * Hyperpigmentation tends to appear in dark-skinned individuals. * Vesicles and bullae are occasionally observed on the hands and feet. * A bulbous enlargement of the distal phalanges has been described. * The most common sites of involvement are the nails (77%), ears (76%), fingers (65%), nose (62%), palms (56%)/ hands (51%), and soles (49%)/feet (44%).

1. Diagnosis 2. give examples of syndromes associated with multiple lesions 3. this gene plays an important role in the pathogenesis of some of these lesions

1. Lipoma 2. see table 3. HMGA2 gene

1. Diagnosis 2. age group commonly affected 3. areas of predilection

1. Nevus lipomatosus superficialis 2. children and young adults in the first decades of life 3. buttocks, upper posterior thighs, and lumbar back

This ncludes** nevus spilus plus organoid nevus** with or without systemic symptoms, which include neurologic deficits and skeletal abnormalities

Phakomatosis pigmentokeratotica

labial melanotic macule

1. diagnosis 2. most commmon CA associated

1. Peutz-Jeghers syndrome 2. colorectal CA

1. identify the syndrome 2. lesions associated

1. PHAKOMATOSIS PIGMENTOVASCULARIS 2. It manifests as a large, metameric **capillary malformation**, usually located on the trunk or the extremities, in association with pigmented cutaneous lesions, such as a **pigmented nevus, a nevus spilus, a café-au-lait patch, or an atypical Mongolian spot** that is not located on the sacrum

Blue rubber bleb nevus syndrome

Maffucci syndrome

1. diagnosis 2. positive stain

1. lymphangioma circumscriptum 2. D2-40

1. diagnosis 2. associated syndromes

1. Angiokeratoma Circumscriptum 2. Cobb syndrome, vascular malformations

1. diagnosis 2. associated syndromes

1. Angiokeratoma Circumscriptum 2. Cobb syndrome, vascular malformations

Variant of angiokeratoma 1. Diagnosis 2. Pattern of inheritance

1. angiokeratoma of Mibelli 2. Autosomal dominant ## Footnote circumscribed, darkred, hyperkeratotic plaques on distal extremities

location: scrotum diagnosis?

angiokeratoma of Fordyce

Associated with intense, burning pain. What is the diagnosis?

ERYTHROMELALGIA

**Acroangiodermatitis** (pseudo-Kaposi sarcoma, congenital dysplastic angiopathy, arteriovenous malformation with angiodermatitis) has purple macules, nodules, or verrucous plaques on the dorsal feet and toes of patients with longstanding venous insufficiency and mimics Kaposi sarcoma clinically and histologically.

Elephantiasis nostras verrucosa ## Footnote Loss of lymphatic drainage from the lower leg may lead to verrucous changes and cutaneous hypertrophy, called elephantiasis nostras

* associated with postmastectomy lymphedema * potential complication in chronically lymphedematous locations

Lymphangiosarcoma (Stewart-Treves syndrome)

1. Diagnosis 2. This may be seen in what type of dyslipidemia? 3. What is the associated defect?

1. xanthoma striatum palmare/ palmar xanthoma 2. Type III dyslipidemia/ dysbetalipoproteinemia 3. Apo E2/2 defect

noninherited variant of xanthoma 1. diagnosis 2. associated syndromes

1. verruciform xanthoma 2. CHILD syndome and epidermolysis bullosa

xanthoma disseminatum

1. diagnosis 2. causative agent 3. treatment

1. Lobomycosis 2. Lacazia loboi 3. surgical removal

diagnosis

rhinosporidiosis

Clue: variant of MF manifesting more often as a hyperkeratotic lesion

PAGETOID RETICULOSIS

Tuberculoid leprosy. A well-circumscribed lesion, with a central macular hypochromic and atrophic appearance, and a peripheric group of papules distributed in annular pattern.

Lepromatous leprosy. Multiples nodules (hansenomes or lepromes) disseminated throughout the skin, associated to diffuse infiltration.

1. diagnosis? 2. etiologic agent

1. ecthyma gangrenosum 2. pseudomonas aeruginosa

1. diagnosis? 2. etiologic agent

1. ecthyma gangrenosum 2. pseudomonas aeruginosa

Acrodermatitis Continua of Hallopeau

Pustulosis Palmaris et Plantaris ## Footnote Palmoplantar pustular psoriasis (PPPP) is a rare variant of pustular psoriasis that is localized to the palms and soles.

GEOGRAPHIC TONGUE Geographic tongue, also known as benign migratory glossitis or glossitis areata migrans, is an idiopathic inflammatory disorder resulting in the local loss of filiform papillae

1. Diagnosis 2. Associated with what arthritis? 3. Inciting infections

1. Keratoderma Blenorrhagicum 2. Reactive Arthritis 3. Chlamydia trachomatis, Yersinia, Shigella, Salmonella, Campylobacter, Clostridium difficile, and Escherichia coli. ## Footnote * cutaenous manifestation of reactive arthritis that resembles a pustular psoriasis and is generally found on the **palms and soles. ** * Initially it is an erythematous vesicular lesion that develops into pustular keratotic lesions before coalescing into psoriatic-like plaques.

1. Diagnosis 2. Associated with what arthritis?

1. Keratoderma Blenorrhagicum 2. Reactive Arthritis ## Footnote * cutaenous manifestation of reactive arthritis that resembles a pustular psoriasis and is generally found on the **palms and soles. ** * Initially it is an erythematous vesicular lesion that develops into pustular keratotic lesions before coalescing into psoriatic-like plaques.

1. Diagnosis 2. associated with what type of arthritis?

1. Cirnate balanitis 2. Reactive Arthritis

1. Identify the sign 2. Associated comorbidity

1. Frank Sign 2. Coronary Artery Disease

1. Diagnosis 2. Disease associations

1. Koilonychia 2. Hemochromatosis and Iron deficiency anemia

1. Identify the lesions 2. Diagnosis

A - “Ash-leaf” hypopigmented macules; B - Shagreen patch;C - Periungual fibroma (Koenen tumor) Tuberous Sclerosis Complex

1. Identify the lesions 2. Diagnosis

A - Fibrous cephalic plaque; A - B - Facial angiofibromas;C - Intraoral fibroma;D - Dental enamel pits Tuberous Sclerosis Complex

1. Diagnosis 2. Causative organism 3. Treatment (with dose)

1. Cutaneous Larva Migrans 2. Ancylostoma braziliense, Ancylostoma caninum 3. Albendazole 400 mg PO daily x 3 days

1. diagnosis 2. treatment of choice

1. Pediculosis palpebrarum or Phthiriasis palpebrarum 2. Ivermectin

Acanthoma Fissuratum

What do you call this bilateral subtype of keratinocytic epidermal nevi?

ichthyosis hystrix ## Footnote * bilateral subtype of keratinocytic epidermal nevi * unilateral subtype is termed nevus unius lateris

Linear and whorled nevoid hypermelanosis ## Footnote * Hyperpigmented patches * DDX: Incontinentia pigmenti stage 3

nevus comedonicus

1. Diagnosis 2. Structures characteristically present in the cyst walls

1. Dermoid cyst 2. Adnexal structures

1. Diagnosis 2. Major associated internal malignancy

1. Maffucci Syndrome 2. Chondrosarcoma

1. identify the lesion 2. possible syndrome present if located in the frontopalpebral area 3. what ophthalmologic condition is often present? 4. patients with this syndrome is high risk of what?

1. Capillary malformation/ Port-wine stain 2. Sturge Weber Syndrome 3. Glaucoma 4. epilepsy and mental retardation

angiokeratoma of Fordyce ## Footnote very common hyperkeratotic, blue-black papules on the scrotum of elderly men)

1. Diagnosis 2. Associated HPV subtypes 3. at risk of progression to what CA?

1. Erythroplasia of Queyrat (EQ) 2. HPV 8 and 16 3. SCC

1. Diagnosis 2. Associated with high mutation rate of what tumor-suppressor gene

1. Erythroplakia 2. p53

Clue: Variant of BCC

FIBROEPITHELIOMA OF PINKUS ## Footnote It may be difficult to distinguish from an acrochordon or skin tag

Clue: Variant of BCC

Fibroepithelioma of pinkus ## Footnote FEP classically presents as a pink papule, usually on the lower back. It may be difficult to distinguish from an acrochordon or skin tag.

Identify this presentation of verrucous SCC in the genitoanal region

giant condyloma acuminatum Buschke-Löwenstein

What do you call this presentation of verrucous SCC on the plantar skin

epithelioma cuniculatum

1. Diagnosis 2. Syndromes associated with a predisposition of this lesion

1. Keratoacanthoma 2. Muir-Torre Syndrome and Ferguson-Smith syndrome

1. Diagnosis 2. MC noncutaneous organ involved 3. Mutation observed in 60% of cases 4. Stains used to visualize cells 5. High risk organs

1. Langerhans cell histiocytosis 2. Bone 3. BRAF-V600E 4. CD1a, S100B, CD207 (Langerin) 5. Hematopoietic system/Bone marrow, Liver, Spleen

Langerhans cell histiocytosis

Clue: Systemic Non-LCH 1. Diagnosis 2. Main clinical manifestation 3. hallmark histopath finding

1. Rosai-Dorfman Disease 2. Lymphadenopathy 3. Emperipolesis - different types of BM cells are found in the cytoplasm of histiocytes

Clue: Non-LCH 1. Diagnosis 2. Associated monoclonal gammopathy 3. Contents of the central necrobiotic area on histopath

1. NECROBIOTIC XANTHOGRANULOMA 2. serum monoclonal gammopathy usually of **immunoglobulin G κ and λ** 3. Cholesterol clefts ## Footnote * It is a multisystem disease that affects older adults and it manifests as yellowish plaques and nodules that can ulcerate. * Necrobiotic xanthogranuloma is predominantly located on the trunk, the extremities, and the face (periorbital lesions). * Extracutaneous involvement also has been described, such as of the eyes, heart, skeletal muscle, larynx, spleen, and ovaries. * A systemic association in the form of serum monoclonal gammopathy usually of immunoglobulin G κ and λ type is seen in 80% of necrobiotic xanthogranuloma patients

Clue: Non-LCH 1. Diagnosis 2. Associated monoclonal gammopathy

1. NECROBIOTIC XANTHOGRANULOMA 2. serum monoclonal gammopathy usually of **immunoglobulin G κ and λ** ## Footnote * It is a multisystem disease that affects older adults and it manifests as yellowish plaques and nodules that can ulcerate. * Necrobiotic xanthogranuloma is predominantly located on the trunk, the extremities, and the face (periorbital lesions). * Extracutaneous involvement also has been described, such as of the eyes, heart, skeletal muscle, larynx, spleen, and ovaries. * A systemic association in the form of serum monoclonal gammopathy usually of immunoglobulin G κ and λ type is seen in 80% of necrobiotic xanthogranuloma patients

1. Diagnosis 2. Present or absent at birth? 3. Associated gene mutations

1. Congenital Hemangioma 2. Present at birth 3. GNAQ and GNA11 are reported to cause RICH and NICH

Tufted angioma

Clue: variant of MF manifesting more often as a hyperkeratotic lesion

Pagetoid Reticulosis ## Footnote * localized on the extremities * no extracutanous dissemination

Clue: Cutaneous Lymphoma 1. Diagnosis 2. Positive stain

1. Lymphomatoid papulosis 2. CD30+ ## Footnote * Lymphomatoid papulosis is a chronic, recurrent, and self-healing papulonecrotic or papulonodular skin eruption * The lesions typically involve the trunk and extremities, and lesions in various stages of evolution may be present concurrently.

Clue: Cutaneous Lymphoma 1. Diagnosis 2. Positive stain

1. Diagnosis 2. Drugs most commonly associated

1. Acute Generalized Exanthematous Pustulosis 2. Beta blockers, β-lactam, macrolide and quinolone, antibiotics, anticonvulsants, sulfonamides, calcium channel blockers (diltiazem), and terbinafine

1. Diagnosis 2. First line treatment

1. Chronic bullous disease of childhood 2. Dapsone or sulfapyridine