What is the new use of rapamycin in cats
Rapamycin is a macrolide that appears to have beneficial effects on the progression of feline HCM
- it may also offer potential benefits for other chronic conditions such as CKD and neoplasia
What is the mechanism of action of rapamycin
The benefits of rapamycin are primarily attributed to its inhibition of mTORC1, while many adverse effects arise from mTORC2 inhibition
- the mTOR signaling pathway plays a key role in the multifactorial process of aging
Explain why rapamycin could be useful in oncology
Given that mTORC1 activity promotes protein synthesis, cell growth and proliferation, this pathway may represent a therapeutic target for a subset of feline mammary carcinomas, squamous cell carcinomas and potentially other neoplasms
How is rapamycin acting in HCM
It has an inhibitory effect on left ventricular hypertrophy
