Readings

Question 1

FHM

Answer 1

• 1-3 day migraine
• Headache + vomiting
• Pore-forming Ca region mutation = hemiplegic migraine w progressive cerebellar ataxia

Question 2

EA2

Answer 2

• Ataxia, maybe: vertigo, nausea & headaches
• Brought on by emo-stress, exercise & alcohol
• Ca chans = truncated @ diff sites`

Question 3

CSNB

Answer 3

• X-linked recessive
• Night blind, myopia, nystagmus & strabismus
• Rods = disfunctional
• Ca chans = truncated

Question 4

Generalized Epilespy w Febrile Seizures

Answer 4

• Infancy –> early puberty
• -Chrom2 mutation encodes alpha subunit
• -Chrom19 mutation slows Na activation

Question 5

Benign Familial Neonatal Convulsion

Answer 5

-Mutation in 2 diff genes = K chan mutation = convulsions/ brief seizures from 1st week –> few months

Question 6

EA1

Answer 6

• Defect in VGK chan = brief ataxia episodes

- Defect of diff VGK chan inhibits fcn of normal ones

Question 7

Pupillary Light Reflex

Answer 7

Pretectum –> Pretectal Neurons sent –> Edinger Westphal Nucleus –> Preganglionic Parasympathetic Neurons terminate on –> neur of Ciliary Ganglion (via Cranial Nerve 3) = constrictor muscles of iris

Question 8

Hubel & Wiesel

Answer 8

• Cat

- Processing in Visual System

Question 9

Hodgkin, Huxley & Eccles

Answer 9

• Ions behind IPSP & EPSP

- Voltage Clamp Technique

Question 10

Neher & Sakmann

Answer 10

• Single ion channel function

- Patch-clamp

Question 11

Shimomura, Chalfie & Tsien

Answer 11

-Green fluorescent protein - GFP