What is the most common cause of red eye?
Red eye is a common presentation in primary care and is a sign of inflammation.
Most cases will be due to relatively benign problems. The most common cause of red eye presenting in a primary care setting is conjunctivitis.
A small proportion of cases are serious and need urgent treatment.
What are the common causes of red eye?
Conjunctivitis Blepharitis Glaucoma Uveitis Iritis Scleritis Episcleritis Corneal abrasion Foreign body Keratitis Chemical burn
What do you ask in the hx of a px presenting with red eye?
History:
Past ocular hx:
General health issues
Social hx:
What do you examine in a px presenting with a red eye?
Essential to record the VA in both eyes
If no ocular causes emerge, consider potential systemic causes.
Scleritis and episcleritis are associated with connective tissue diseases such as RA, gout, syphilis, sarcoidosis and HTN.
What are the causes of acute painful red eye?
Acute angle-closure glaucoma Keratitis Acute anterior uveitis Trauma- foreign body or corneal abrasion Endophthalmitis Scleritis
What are the causes of acute non-painful red eye?
Conjunctivitis
Episcleritis
Subconjunctival haemorrhage
What are the causes of non-acute red eye?
Acne rosacea Canaliculitis Blepharitis Lagophthalmos Floppy eyelid syndrome Trichiasis Inflamed Pinguecula Stevens-Johnson syndrome
What is inflamed pinguecula?
A pingueculum is a common, innocuous lesion seen as a cluster of yellow-white deposits (usually in a triangular formation with the base adjacent to the cornea), arranged temporally or nasally to the cornea.
It results from degenerative change in the sclera from environmental irritants, including sunlight.
If it becomes inflamed (pingueculitis), it becomes red and may be elevated, sore or ulcerated.
What is the management of a red eye?
Urgent referral for potentially serious problems.
Which features are suggestive of a serious condition which may warrant urgent referral in a px of red eye?
Moderate-to-severe eye pain or photophobia.
Marked unilateral redness. The greater the redness, the more likely it is that the cause is serious.
Ciliary injection, which is not always obvious, is suggestive of inflammation of deeper structures. It is indicated by redness and dilated blood vessels that can be seen between the sclera and the iris.
Reduced VA.
Photophobia or seeing coloured haloes around point sources of light.
Copious purulent discharge (particularly in neonates).
Corneal involvement.
Known or suspected eye trauma.
Recent ocular surgery.
Pupillary distortion or abnormal reaction.
Herpes simplex or herpes zoster.
Recurrent episodes.
Proptosis.
Contact lens wear.
What is conjunctivitis?
This is the inflammation of the conjunctiva.
Associated corneal involvement give rise to keratoconjunctivitis.
Eyelid involvement suggests blepharoconjunctivitis.
It can be classified as infectious or non-infectious, and as acute, chronic, or recurrent.
It can affect any age group. There is no gender, ethnic or social preponderance.
What is the presentation of conjunctivitis?
Red eye, which is usually generalised, often bilateral.
Irritation, grittiness and discomfort are typical; significant pain suggests alternative diagnoses.
Discharge, which may be watery, mucoid, stickly or purulent.
Photophobia is not typical.
VA should be unaltered.
Signs include:
Conjunctival chemosis
Conjunctival injection with dilated conjunctival vessels
Follicles or papillae
Corneal involvement (this occurs rarely): oedema, neovascularisation and punctate epithelial erosions.
What are follicles?
Follicles are round collections of lymphocytes, most prominent in the inferior fornix, which appear as small, dome-shaped nodules, pale at the top and without prominent central vessels, although blood vessels may overlie them.
They are typically seen in conjunctivitis caused by viruses, atypical bacteria and toxins, including some topical medications (especially brimonidine).
What is a papillae?
Papillae have a cobblestone appearance of flattened nodules with central vascular cores, appearing red on the surface and pale at the base.
They are most commonly associated with an allergic immune response, as in vernal and atopic keratoconjunctivitis, or as a response to a foreign body such as a contact lens. Papillae coat the tarsal surface of the upper eyelid and may reach large size (giant papillary conjunctivitis).
How do you assess conjunctivitis?
Ask about:
What do you do in the exam for conjunctivitis?
Exam:
What are the investigations of conjunctivitis?
Generally, the diagnosis is rapidly made following history and examination but further investigations are warranted (referral to a specialist) in the following circumstances:
What are the differentials of conjunctivitis?
Uveitis Glaucoma Herpes zoster ophthalmicus Keratitis Scleritis and episcleritis Foreign body Trauma
What are the classification of conjunctivitis?
Viral Bacterial Allergic Chronic Cicatricial Giant papillary Parinaud’s oculoglandular syndrome Pediculosis
What are the causes of viral conjunctivitis?
Adenovirus
HSV
Herpes zoster ophthalmicus (HZV)
Molluscum contagiosum
What are the causes of bacterial conjunctivitis?
Bacterial conjunctivitis- most commonly caused by staphylococcus spp. Streptococcus pneumoniae, H. influenzae and Moraxella catarrhalis.
Hyperacute conjunctivitis
Chlamydial conjunctivitis
Conjunctivitis is sometimes seen in Lyme disease, although it more often leads to additional, deeper eye inflammation.
What is chronic conjunctivitis?
Most bacterial and viral infections resolve spontaneously within two weeks.
Chlamydial infections and some bacterial infections can cause chronic conjunctivitis lasting for weeks or months if untreated.
Causes of chronic conjunctivitis include:
Follicles present:
-With preauricular lymph nodes
Suggests toxic conjunctivitis, molluscum, pediculosis.
-Without preauricular lymph nodes
-With herpetic signs: suggests HSV conjunctivitis.
-Without herpetic signs: suggests adenoviral conjunctivitis or chlamydia.
Papillae present:
What is cicatricial conjunctivitis?
This refers to a group of inflammatory conditions affecting the conjunctiva.
They lead to scarring (the term cicatricial means scarring), loss of function and, potentially, loss of sight.
All should be referred urgently for ophthalmological review.
Causes:
-Ocular mucous membrane pemphigoid
-Erythema multiforme, Stevens-Johnson syndrome, TENS
Secondary causes:
What is infective conjunctivitis?
Bacterial conjunctivitis is usually a benign self-limiting illness.
However, it can sometimes be serious or signify a severe underlying systemic disease. Occasionally, significant ocular and systemic morbidity may result.
Viral conjunctivitis can be prolonged and can, in some cases, have lasting consequences.
Adenoviral infection is usually (but not always) mild and self-limiting, whereas herpes viruses can cause significant associated keratitis and uveitis.