1
Q
Chol –> Pregenolone enzyme
A
IN THE MT MEMBRANE!
20,22 desmolase (27-21 C) - this conversion stimulated by LH
2
Q
Testosterone –> DHT enzyme
A
5-a-reductase (DHT CANNOT be converted to estrogens)
3
Q
Androgens –> estrogens enzyme
A
aromatase in adipose tissues, liver and CNS
4
Q
Estrogen types
A
E1: in fat (estrone) (from androstenedione)
E2: estradiol (in ovaries) MOST POTENT - granulosa cells of ovaries, sertoli cells of testes KEY FEEDBACK INHIB on Hypo and Pit
E3: estriol (in placenta) LEAST POTENT
5
Q
Sex steroid binding proteins?
A
Right, since they are hydrophobic:
albumin
SHBG (WILL RISE WITH EXOGENOUS ESTROGENS - hepatic synthesis)
CBG (corticosteroid binding globulin)
DEMS 4
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