1
Q
Which chromosome is the CFTR gene located on?
A
Chromosome 7
2
Q
Mechanism of Ivacaftor?
A
Potentiates defective G551D CFTR proteins
3
Q
Wells Criteria for PE
A
Dvt clinical signs and symp- 3 PE is most likely dx - 3 Heart rate >100 - 1.5 Immobility 3 days or surgery in past 4 weeks - 1.5 Previous PE/DVT - 1.5 Haemoptysis - 1 Malignancy - 1
4
Q
What is the mechanism of ambrisentan/nose tan/macicentan.
A
Endothelin receptor antagonist
5
Q
What class of drug is riociguat a part of?
A
Guanylate cyclase stimulator
6
Q
What is the mechanism of selexipag?
A
Prostacyclin pathway agonists
7
Q
What hounsfield unit would you expect for malignant nodules?
A
> 20
8
Q
In the setting of pulmonary nodules, what are the high risk features for malignancy?
A
Older age Smoking history Larger nodules Irregular or speculated Upper lobe lesions
9
Q
What is the most sensitive test for asthma?
A
Methacholine challenge
10
Q
What is the most specific test for asthma?
A
Post bronchodilator reversibility
