Respiratory: COPD

Question 1

Where do M1 receptors act?

Answer 1

At the ganglia- the facilitate transmission mediated by ACh on nicotinic receptors

Question 2

Where do the M2 act?

Answer 2

Post ganglionic- reduce ACh production

Question 3

Where do M3 act?

Answer 3

Smooth muscle- mediate contraction to ACh

Question 4

What does activation of M3 receptors cause

Answer 4

coupling with Gq receptors activates phospholipase C which increases Calcium induced calcium release from SR and causes contraction

Question 5

Name two SAMAs

Answer 5

Ipratropium

Oxitropium

Question 6

Name two LAMAs

Answer 6

Tiotropium

Aclidinium

Question 7

Which one is non selective?

Answer 7

Ipratropium

Question 8

Whihc receptro do you not want to block

Answer 8

M2

Question 9

Name an ultra LAB

Answer 9

indacaterol

Question 10

What other drug can be used to control COPD?

Answer 10

Phosphodiesterase 4 inhibitors

Question 11

Name a PDE4 inhibitor

Answer 11

Rofumilast