Resting TV
0.5l
Resting f
12
Resting MV
6l
Exercise TV
5l
Exercise f
40
Exercise MV
200l
Mechanics of breathing: inhalation at rest
External intercostals and diaphragm
Mechanics of breathing: inhalation during exercise
External intercostals
Diaphragm
Sternocleidomastoid
Pectoralis minor
Mechanics of breathing: exhalation at rest
Passive process
Mechanics of breathing: exhalation during exercise
Internal intercostals and rectus abdominis
RCC
Respiratory Control Centre, located in medulla oblongata
Four receptors for RCC
Chemoreceptors
Thermoreceptors
Proprioreceptors
Thermoreceptors
Inspiratory centre
Controls inspiration by sending signals along phrenic and intercostal nerves and recruits other muscles during exercise
Increases TV
Expiratory centre
Inactive at rest, during exercise detects increase in pressure and recruits muscles to increase f
External respiration
Takes place at alveoli
Internal respiration
Takes place at muscles
Haemoglobin
Each red blood cell has many haemoglobin molecules
Each haemoglobin has 4 binding sites for oxygen - first hardest, 2&3 easy, 4 difficult
High affinity meaning (relative)
Oxygen binds easily but can’t be released
Low affinity meaning (relative)
Oxygen is released easily but can’t be picked up - at muscles haemoglobin has lower affinity than myoglobin
Oxyhaemoglobin dissociation curve
Oxyhaemoglobin saturation against ppO2 (sigmoid curve)
Diffusion definition
Movement of a substance from an area of high pp to an area of low pp
Left shift
Curve shifts left for higher affinity (external at altitude)
Right shift (Bohr shift)
During exercise curve shifts right at muscles to release more oxygen
Factors causing Bohr shift
Decrease in ppO2
Increase in ppCO2
Decrease in pH
Increase in temperature