Review

Question 1

Hematopoiesis- stem cell factor

Answer 1

C-kit ligand

Question 2

Hematopoiesis - myeloid cells

Answer 2

IL-3

Question 3

Hematopoiesis -Granulocytes and monocytes

Answer 3

GM-CSF

Question 4

Hematopoiesis - eosinophils

Answer 4

Il-5

Question 5

Hematopoiesis - Basophils, mast cells

Answer 5

IL-3

Question 6

Hematopoiesis - NK cells

Answer 6

IL-15

Question 7

Hematopoiesis - B cells

Answer 7

IL-7

Question 8

Hematopoiesis - T cells

Answer 8

IL-7 and Notch-1

Question 9

PAMPs - gram +

Answer 9

Peptidoglycan

Question 10

PAMPs - trypanosomes

Answer 10

GPI-linked protein

Question 11

PAMPs Yeast, Fungi

Answer 11

Zymosan

Question 12

PAMPs viruses

Answer 12

DsRNA, ssRNA

Question 13

PAMPs gram - bacteria

Answer 13

LPS

Question 14

Bacteria

Answer 14

Flagellum

Question 15

PAMPs bacterial DNA

Answer 15

CpG unmethylated dinucleotide

Question 16

TLR2

Answer 16

Peptidoglycan, CPI linked protein, zymosan

Heterodimer

Question 17

TLR3

Answer 17

DsRNA

Question 18

TLR4

Answer 18

LPS

Question 19

TLR5

Answer 19

Flagellin

Question 20

TLR7

Answer 20

SsRNA

Question 21

TLR8

Answer 21

ssRNA

Question 22

TLR9

Answer 22

CpG unmethylated dinucleotides (bacterial DNA)

Question 23

CLRs

Answer 23

Mannose receptor
Dectin 1
Bacteria, fungi, parasite

Phagocytosis

Question 24

RLRs

Answer 24

DsRNA
Cytosolix
IFN alpha and beta

Question 25

NLRs

Answer 25

Bacterial cell wall components | Cytosolic

Question 26

Secreted peptides and protein Defending and cathelicidin (3 functions)

Answer 26

Inhibit and kill pathogens Chemoattractant Degranulate

Question 27

Secreted peptides and protein IFN alpha and beta 2 functions

Answer 27

Inhibit virus replication, regulate activity

Question 28

Secreted peptides and protein | IL-1 (3 functions)

Answer 28

Enhance lymphocyte activity Promote neutrophil production Fever

Question 29

Secreted peptides and protein | IL-6 (3 functions)

Answer 29

Regulate lymphocyte activity Produce neutrophils Fever

Question 30

Secreted peptides and protein TNF alpha (3 functions)

Answer 30

Activate macrophages Fever Blood clotting

Question 31

Secreted peptides and protein | IL-12, IL-18

Answer 31

Induce Th1 differentiation IFN-gamma production Activate naive CD8+ and nk cells

Question 32

Secreted peptides and protein | IL-10

Answer 32

Antagonize inflammatory response

Question 33

Secreted peptides and protein | IL-8

Answer 33

Chemoattractant of neutrophils, basophils, immature DCs, T cells to infection site G-coupled receptor

Question 34

Opsonin | 4 types

Answer 34

Mannose binding lectin (MBL) Ficolins C reactive protein Immunoglobulins

Question 35

Cytokines | TNF alpha, IL-1B, IL-6

Answer 35

``` In response to bacteria products Recruit neutrophils and macrophages Dilate blood vessels, open junctions Cause macrophages to secrète IL-1B Blood clotting, recruit phagocytes and DCs (LFA, iCAM) ``` IL-1B acute phase proteins (opsonins)

Question 36

Cytokines | IL-12

Answer 36

Made by macrophages and DCs in response to LPS, virus, intracellulaire bacteria, IFN-gamma Activates NK; kill and produce IFN-gamma Th1 differentiation to produce IFN-gamma, IL-2 (growth factor), IL-R

Question 37

Cytokines | IFN-alpha and beta

Answer 37

``` Made in response to DsRNA Alpha: made by macrophages and dc Beta: many cells Indice viral résistant state (down regulate translation, make proteins to inhibit viral replication, upregulate MHC class 1) Activate NK, kill and produce IFN-gamma ```

Question 38

Naive Th cell + TGF-beta

Answer 38

Treg

Question 39

Naive Th cell + IL-1B, IL-6, TGF-beta

Answer 39

Th17

Question 40

Naive Th cell + IL-4

Answer 40

Th2

Question 41

Naive Th cell + IFN-gamma and IL-12

Answer 41

Th1

Question 42

Treg secreted

Answer 42

IL-10 TGF-beta Suppress immune response and inflammation

Question 43

Th17 secreted

Answer 43

IL-17 Inflammation

Question 44

Th2 secretes

Answer 44

IL-4, IL-5 Allergic response

Question 45

Th1 secreted

Answer 45

IFN-gamma TNF alpha Cell mediated immunity Macrophage activation Inflammation