Rh

Question 1

If you give Rh pos blood to an Rh neg person, __ to __% will make an anti-D

Answer 1

40-70%

• 1 mL of D positive cells can induce a response
• besides the D antigen, the other main antigens are C, c, E, e

Question 2

Fisher-Race Theory

Answer 2

• closely linked loci where crossing over does not occur
• RHD: Dd
• RHCE: CE, Ce, cE, ce

Question 3

these are polypeptides expressed on the RBC surface, but are associated with a larger amphiphilic protein that weaves back and forth through the cell’s membrane

Answer 3

Rh antigens

Question 4

Rh null

Answer 4

• no Rh antigens (___/___)
• inherited two copies of amorphic gene or inherited a suppressor gene = inhibits patient from expressing antigens
• (D/D) can also happen

Question 5

symptoms of Rh null individuals

Answer 5

• mild, compensated hemolytic anemia

- stomatocytes

Question 6

T or F. Weak D is more common than Rh null

Answer 6

T

Question 7

testing for weak D involves…

Answer 7

IAT (Indirect Antiglobulin Test)

Question 8

must do weak D test to these people

Answer 8

blood donors

- if recipient = if neg then just give neg blood (won’t hurt even if actually weak pos)

Question 9

what happens when partial D blood recipients are given Rh pos

Answer 9

they can make Abs to epitope they lack; IMPORTANT that if patient receiving blood types neg then just give them neg blood

Question 10

We also do weak D test on this population

Answer 10

newborns!
if weak D pos then mother at risk for developing anti-D = next child at risk
- administer RhIg to mom