[ROQs] Benign

Question 1

What is the 5- and 10-yr LC for a desmoid tumor s/p RT or surgery or both?

Answer 1

• 5-yr: 71%
• 10-yr: 69%

Question 2

What are the 5-yr survival rates for FAP-associated desmoid tumors according to stage?

Answer 2

I: 95%
II: 100%
III: 89%
IV: 76%

Question 3

What is the usual RT dose for desmoid tumors?

Answer 3

50-56 Gy

Question 4

What is the primary treatment modality for a new/recurrent desmoid tumor?

Answer 4

• Active surveillance for at least 1 yr
• Growth can trigger tx

Question 5

How do you distinguish b/w desmoid tumor and STS?

Answer 5

• Bx
• No specific imaging characteristics of desmoid tumors
• They appear as low-grade sarcomas w/o the nuclear and cytoplasmic features of a malignancy, mitoses, or necrosis

Question 6

What are the indications for RT for a desmoid tumor?

Answer 6

• Unresectable disease
• Recurrent disease
• R2 resection (residual gross disease)
• • or close surgical margins with no possibility of re-resection

Question 7

Which genetic condition is a/w desmoid tumors?

Answer 7

• FAP
• Desmoid tumors in these pts can form at previous surgical sites, so if they had a colectomy, they could present w/ bowel obstruction and ischemia

Question 8

What % of paraganglogliomas produce catecholamines?

Answer 8

5%

Question 9

What is the RT dose for plantar fasciitis fibromatosis?

Answer 9

e^-: 30 Gy in 10 fx BID

Question 10

What is the RT dose for Kaposi sarcoma?

Answer 10

• 8 Gy in 1 fx
• 24 Gy in 12 fx
• 30 Gy in 10-15 fx

Question 11

What is the cell of origin of Paragangliomas?

Answer 11

• Glomus cells (chemoreceptors along blood vessels)
• Paraganglogliomas aka glomur tumors

Question 12

What is the long-term control rate for glomus tumors s/p RT?

Answer 12

~90%

Question 13

What is the classic SRS and conventional doses for glomus tumors?

Answer 13

• SRS: 12-18 Gy (Avg. 15 Gy)
• CF-RT: 45-54 Gy

Question 14

What % of glomus tumors undergo shrinkage, no growth, and progression post-SRS?

Answer 14

• Shrinkage: ~30%
• No growth: ~60%
• Progression: ~6%

Question 15

What is the classic appearance of paragangloglioams on MRIs?

Answer 15

Salt and Pepper

Question 16

What is the BED required for the tx of keloids?

Answer 16

• BED ≥ 60 Gy

Question 17

What is the first-line treatment for Grave’s ophthalmopathy?

Answer 17

Prednisone: 30 mg/day x 4 weeks

Question 18

What is the RT dose for Grave’s ophthalmopathy?

Answer 18

20 Gy in 10 fx

Question 19

What is the formula for various isodose lines for electrons of incident energy Eo?

Answer 19

• 5-4-3-2 rule! (Dmax, D90, D80, Range)
  – 4 is actually 3.2
  – 3 is actually 2.8

Dx = Eo/x
(X is either 5, 4, 3, or 2 depending on which depth you want!)

Question 20

What is the relative and absolute risk reduction in HO recurrence w/ RT as compared to NSAIDS (Indomethacin, etc)?

Answer 20

• Absolute: ~1%
• Relative: ~50%

Question 21

What medication can be used for gynecomastia ppx for men undergoing ADT?

Answer 21

Tamoxifen

Question 22

What is the RT dose for Duputren’s contracture?

Answer 22

• 30 Gy in 10 fx w/ an 8 week break halfway through RT
• 21 Gy in 7 fx

Question 23

What is the RT dose for gynecomastia?

Answer 23

• e^- to the 85% IDL. R_x include:
  – 12 Gy in 3 fx
  – 10 Gy in 1 fx
• no bolus

Question 24

What is the staging system for glomus jugulare tumors?

Answer 24

Glomus Jugulare → Glasscock Jackson