What does RSV cause?
severe lower respiratory infection, esp in young children
What time of year does RSV infect people?
winter and spring, annually
How is RSV spread?
large droplets; can live on surfaces for 1 hour
How many strains of RSV are problematic?
2- A and B
RSV is the most common cause of _____.
bronchiolitis
Does pre-existing immunity protect someone from RSV?
no- it rapidly evolves like influenza
RSV is a _____, _____ virus.
ss, non-segmented RNA
What are the 2 subtypes of RSV? Which is more severe? What are the 2 proteins to know?
A and B; A causes a worse disease and is more prevalent; F protein (fusion) and G protein (binding)
What does F protein do?
fusion of viral envelope, membranes, causes synctia
What does G protein do?
allows initial binding of virus to the host cell
Where does RSV invade?
the conjunctiva/nasopharynx
What is the incubation period for RSV?
3-5 days
What are the clinical signs/symptoms of RSV?
respiratory distress, wheezing/rhonchi, hypoxia, copious secretions, mucous plugging
What happens in the airway with RSV?
constriction of smooth muscle in the bronchioles, Get edema/inflammation, ventilation/perfusion mismatch, hyperexpansion, mucous plugging
How do you test for RSV?
cell culture, direct antigen detection, nucleic acid/genome PCR (best)
Having RSV as a child may predispose the adult to?
wheezing
What was the problem with the RSV vaccine?
didn’t confer protective immunity and children who received it actually got worse disease; showed risk of priming for infections
What is the RSV prophylaxis?
Palivizumab (Respigam) or Palavisumab (Synagis), pooled Abs; decreases severity and hospitilizations
Who receives RSV prophylactic treatment?
children in high risk groups
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Influenza29
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RSV19
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Ebola10
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Virus Properties40
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Common Viral Pathogens55
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Antiviral Agents68
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Viral Pathogenesis and Host Resp23
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Hemostasis 220
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Platelet Effects21
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Hemostasis 122
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Parasites12
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Fungi27
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Virus Structure and Function15
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Hemostasis Defects18
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Immunomodulators13
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Combined Hemostasis44
