Tenofovir disoproxil fumarate/ Emtricitabine (Truvada™)
More well studied
Indication: All people at risk through sex or injection drug use
Kidney impairment
Bone demineralization
Tenofovir alafenamide/ emtricitabine (Descovy™)
Indication: People at risk through sex EXCEPT those assigned female at birth at risk from vaginal sex
Associated with weight gain
Pre-Exposure Prophylaxis (PrEP)
Pro
Pre-Exposure Prophylaxis (PrEP)
Con
PrEP Counseling
Takes 21 days to be effective
7 days for anal tissue
21 days for vaginal tissue and for injection drug use
Unknown time for insertive anal or vaginal sex
While on PrEP, you should still use a condom to prevent against other STIs and pregnancy
True
while on PrEP, you must get labs every 3 months and see a provider to renew the prescription
Screen for HIV and other STDs
Ensure kidney function is adequate
True
Risky sexual behaviors
Condoms reduce risk of transmission by ~ 80%
If penal condoms are not preferred, can use vaginal condom and remove inner ring as an anal condom
Circumcised men are less likely to get HIV from vaginal sex than uncircumcised men
True
Undetectable = Untransmissable (U = U)
True