Mechanism of action of direct adrenergic agonists
A. Increases synthesis of NE
B. Binds and activates adrenergic receptors
C. Inhibition of MAO
D. Inhibits reuptake from synaptic cleft
B
Adrenergic receptor on JG Cells
A. Alpha 1
B. Alpha 2
C. Beta 1
D. Beta 2
C
this drug with can improve contractility but can also cause vasodilatation should not be taken as a sole adrenergic drug in patients with heart failure and hypotension
A. Dobutamine
B. Dopamine
C. Norepinephrine
D. Phenylephrine
B
Selective beta-2 adrenergic agonists are useful in which of the following conditions
A. Hypertension
B. Heart failure
C. Preterm labor
D. Arrythmia
C
Sympathomimetic effects in the CNS include the following EXCEPT:
A. Excessive urge to sleep in inappropriate situations
B. Elevation of mood
C. Euphoria
D. Psychosis
A
A beta-1 selective blocker with partial activity which will minimize, if not prevent precipitation of asthma and bradycardia.
A. Acetabulol
B. Timolol
C. Propanolol
D. Esmolol
A
Incorrect association between histamine and its distribution in organs.
a. H1 – extravascular smooth muscle
b. H2 – gastric parietal cells
c. H3 – CNS
d. H4 - myocardial cells
D
not H1 antagonist
a. cimetidine
b. chlorophenydramine
c. diphenhydramine
d. loratidine
A
Incorrect about Kallikrein-kininogen-kinin/KKK system:
a. Bradykinin causes vasodilation and cough
b. High molecular weight kinninogen is important in activation of intrinsic clotting pathway
c. Aprotinin which inhibits kallikrein à reverse bleeding due to heparin
d. Tissue damage cannot activate KKK
D
Not a function of 5ht
a. Regulation of GI motility and peristalsis
b. Bronchodilation
c. Central chemical transmitter for tryptaminergic neurons of the brain
d. Precursor of melatonin
B
Incorrect match between the 5HT receptor antagonist / agonist drugs with their clinical use
a. 5HT3 Antagonist / ondansetron – nausea, vomiting
b. 5HT4 agonist / Cisapride – anxiety/depression
c. 5HT 1D agonist / Sumatripan – migraine
d. 5HT2A Antagonist / Ketaneserin – hypertension
B
Example of non-selective 5HT receptor antagonist:
a. Buspirone
b. Trazodone
c. Ergotamin
d. Ketanserin
C
The gastrointestinal bleeding from aspirin is considered:
a. side effect
b. extension effect
c. drug toxicity
d. medication error
A
- Autacoids involved in inflammatory reaction, EXCEPT
a. Histamine
b. Bradykinin
c. Serotonin
d. Prostanoids
e. Angiotensin II
E
The following physiologic effects are mediated by histamine EXCEPT
a. Vasodilatation
b. Increased vascular permeability
c. Relaxation of intestinal smooth muscles
d. Stimulation of sensory nerve endings
C
H1 blockers (traditional / older antihistamines) have the following effects:
a. Promote sedation
b. Relieve allergic manifestations on the skin and mucous membrane
c. Emesis
d. All of the above
e. A and B only
D
Which of the following is least sedating
a. Loratadine
b. Chlorpenamine
c. Diphenhydramine
d. Clemastine
A
What are the therapeutic uses of the H1 blockers? ALL EXCEPT
a. As a sleeping aid
b. For countering motion sickness
c. To moisten the mouth and throat
d. To relieve itching and rashes in allergic disease
C
Body functions where 5-HT in involved
a. Fertility
b. Feeding
c. Sleeping
d. Mentation
e. All of the above
E
The enzyme responsible for converting tryptophan to serotonin belongs to what class
a. Lipoxygenase
b. Hydroxylase
c. Peroxidase
d. Transferase
B
Prostanoids have the following actions/clinical significance
a. Platelet function
b. Inflammatory reaction
c. Reproduction
d. A and B only
e. All of the above
E
Which of the following anti-inflammatory agents is unique that it binds to its receptor irreversibly?
a. Ibuprofen
b. Mefenamic acid
c. Acetaminophen
d. Aspirin
D
An example of lipoxygenase inhibitor is:
a. Celecoxib
b. Zileuton
c. Montelukast
d. Misoprostol
B
Histamine
a. has powerful effects on smooth and cardiac muscles
b. endothelial cells and nerves
c. more effect on guinea pigs than humans
d. gastric acid secretion
e. AOTA
E
