SCC

Question 0

In a study of 17 cats receiving an accelerated protocol of electrons for nasal planum SCC:

1. Impact of Ki67?
2. How did this protocol compare to standard DRT protocols?

Answer 0

1. increased Ki67, increased DFI

2. comparable

Question 1

In a study of 90 cats w nasal planum SCC receiving DRT:

1. The difference survival for T1 vs. T3/T4?
2. What marker was px for tumor control?

Answer 1

1. T1 lived longer (53 vs 15-19 mos)

2. PCNA

Question 2

Regarding Sr-90 for nasal planum SCC in cats, what is the CR rate?

Answer 2

87-88%

Question 3

In a study of 49 cats receiving Sr-90 for nasal planum SCC:

1. MST?
2. How did cats w CR compare to those w/o?

Answer 3

1. MST 103 mos

2. cats w CR lived 103 (vs 19)

Question 4

In a study of 15 cats with nasal planum SCC, for what stages is Sr-90 a good treatment?

Answer 4

Stages ≤ T2

mDFI was 22 mos in this study

Question 5

In a study of 15 cats with nasal planum SCC treated with protons, how did the outcome compare with standard DRT protocols?
MST?

Answer 5

Comparable

31 mos

Question 6

In general, regarding nasal planum SCC in cats:

1. Metastatic rate?
2. Why do new sites of disease develop?
3. Later stage disease may require nosectomy - what is MST??

Answer 6

1. 40%
2. because underlying causes are not reversed
3. 22mos

Question 7

In general, regarding nasal planum SCC in cats what is the strongest predictive factor?

Answer 7

stage

Question 8

Do cutaneous SCC in cats express COX-2?

Answer 8

No, which is why piroxicam doesn’t work.

Question 9

In cats with oral SCC treated w PRT alone or PRT + gemcitibine MSTs range from…

Answer 9

2-4 mos

PRT alone 2 mos in one study, 3 mos in another, add gemcitabine in another 4 mos

Question 10

In a study of 9 cats given an accelerated RT protocol (3.5 Gy x 14) for oral SCC:

1. MST??
2. How did cats w lingual tumors do?

Answer 10

1. 3 mos

2. worse - 2 mos vs 8 mos

Question 11

In a second study of cats w oral SCC treated w accelerated RT adding carboplatin:

1. Compare tonsil/buccal to tongue/maxilla/mandible.
2. How did cats w CR do?
3. Effect of stage and size of tumor?

Answer 11

1. better. MST NR vs 5 mos
2. better. MST 13 vs 4 mos
3. No bearing on survival

Question 12

In a study of 21 cats w oral SCC, accelerated RT (48 Gy over 12 days) ± carboplatin, what was the PFS for each stage?

Answer 12

T1 20 mos
T2 3.5 mos
T3 2 mos
(ORR 70%)
(Poirier)

Question 13

Cats w oral SCC treated w mandibulectomy & post-op RT had MST of…

Answer 13

14 mos

Question 14

In general, the risk of oral SCC in cats is ____x w use of flea collars and intake of canned food in general (especially canned _____).

Answer 14

3.5…..tuna

Question 15

In cats, smoke exposure significantly increases ______ ______ in SCC, ETS increases risk of oral SCC by ___x (not sig)

Answer 15

p53 expression……2

Question 16

For cats with oral SCC, RT + etonidazole has a PR of ____% and MST of ___ mos.

Answer 16

100….4

Question 17

What are COX-1 and COX-2 expression in feline oral SCC?

Diffuse COX-1 staining increased hazard of dying by ___x.

Answer 17

100% COX-1
75% COX-2
4

Question 18

___ Ki67 score correlates with increased MST in feline oral SCC

Answer 18

low

Question 19

S-lipoxygenase expression is high in oral SCC. ______ is a lipoxygenase inhibitor and _____ _____ in SCC cells.

Answer 19

tepoxaline

induces apoptosis

Question 20

In one study of oral SCC in cats, what are increased risks with:
flea collars?
canned food?
canned tuna?
ETS?

Answer 20

5, 3, 4, 2

Question 21

In nasal planum SCC in dogs:
\_\_\_% metastatic rate
When treated w RT:
\_\_\_-\_\_\_% recurrence rate treated 
Durability of response?

Answer 21

24
75 to 100
responses achieved are not durable
(MST 6 mos)

Question 22

In a study of 39 dogs w non-tonsillar SC:
RT + sx MST??
RT alone MST??
Stage II ___x & Stage III ___ x were at higher risk of local recurrenc vs Stage I tumors

Answer 22

34 mos
16 mos
2.8…6.4

Question 23

In a study of 33 dogs treated with orthovoltage for non-tonsillar SCC:

1. Longer DFI: maxillary vs mandiublar/ST?
2. Live longer: rostral vs caudal/(rostral to caudal)?
3. Live longer: ___ yrs of age?
4. Dogs w/o local recurrence?

Answer 23

1. maxillary longer (12 vs 3/2 mos)
2. Rostral longer (28 vs 10/2 cd/[rostral to cd])
   3.

Question 24

In a study of 14 dogs treated for non-tonsillar SCC, the MST was ____mos and dogs ____ years of age had significant longer MSTs, ____ mos vs ____mos. MV vs orthovoltage?

Answer 24

15....<9.....36...10 | MV was superior at 15 vs 9 mos

Question 25

The metastatic rate of non-tonsillar SCC in dogs is _____ (low/high). ___% to LN ___% to lung

Answer 25

low 10% 3-36%

Question 26

In canine non-tonsillar SCC, surgery alone results in what MST for mandibulectomy and maxillectomy?? RT recurrence??

Answer 26

Mandible 19-26 mos, 10% recur Maxilla 10-19 mos, 29% recur 30%

Question 27

Lingual SCC in dogs treated w RT has a MST of ____mos?

Answer 27

4

Question 28

In a recent study of 44 dogs w treated w chemo + RT for tonsillar SCC, the MST was ___ mos: 1. Dogs w _____ or ____had sig shorter MST 2. dogs w any tx lived longer than those w symptomatic care/no tx: ____ vs ____ mos 3. Who lived longer: chemo or chemo+RT vs Sx alone? MSTs?

Answer 28

12 mos 1. anorexia...lethargy 2. 7...2 3. chemo/chemo+RT; 7/12 vs 5 mos

Question 29

In a study of 44 dogs w tonsilar SCC treated w chemo or chemo+RT vs Sx alone, did surgery prolong survival?

Answer 29

No

Question 30

Regarding tonsillar SCC in dogs: 1. Metastasis early or late in disease? 2. ___% metastatic rate 3. ___x more common in rural or urban dogs? 4. ___% have systemic disease at dx.

Answer 30

1. early 2. 73 3. 10, urban 4. >90

Question 31

In tonsillar SCC in dogs, RT 1 yr survival is ___% RT+chemo is ____mos

Answer 31

11 12 ??