Screening tools

Question 1

Goal of PCa screening?

Answer 1

early detection

Question 2

Digital rectal examination - DRE

Answer 2

• specificty
• low cost
• safe + ease
• only moderate sensitivity

Question 3

what is prostate-specific antigen - PSA a marker for?

member human kallikrein gene - serine protease - produced in coloumnar secretroy cells of prostate

Answer 3

• detected early PCa
• predict outcome localized disease
• monitor disease-free status
• monitor response to treatment of advance-stage disease

Question 4

Advantages of PSA

Answer 4

• Non-invasive
  -ease
  l- low specificity - elevated in men who are smokers , cases urinary retetnion, acute prostatitis, BPH
  = not all men with PCa have high PSA

Question 5

Is 5-alpha reductase inhibitors recommended for PCa ?

Answer 5

No, as it can cause higher grade tumours