Sedative/Hypnotic

Question 1

Define Axiolytic

Answer 1

Sedation, reduce anxiety, CNS suppresion

Question 2

Benzodiazapines Pharmacodynamics

Answer 2

Potentiate GABAergic inhibition at all levels of CNS, BZ binding sites are part of GABA-A receptor, the BZ do not directly activate the receptor but they enhance the effect of GABA binding=greater inhibition

Question 3

Barbiturates Pharacodynamics

Answer 3

Interact w/GABA by increasing duration of the GABA gated chloride channel opening

Question 4

Dangerous effect of axiolytic and anesthetics

Answer 4

At higher doses may induce anterograde amnesia-inability to remember event while using drug, induce “date rape”

Question 5

Patient has a difficult time following directions, seem drowsy and have diminished motor skills. What medication would cause these adverse effects?

Answer 5

Benzodiazepines and Barbiturates: Daytime drowsiness, impaired judgement, diminished motor skills, adverse impacts on driving ability, job performance, personal relationships, can’t learn new info

Question 6

Diazepam (valium) acts as what two drug types?

Answer 6

1. ) Benzodiazepine: Sedative and pre-anesthesia anxiety releiver
2. ) Antispasmolytic: Muscle Relaxor

Question 7

List the Newer Hypnotic Drugs

Answer 7

Lunesta, Ambien, Sontata, BuSpar

Question 8

New Hypnotic Drugs also treat what besides acting as a sedative

Answer 8

Treat epilepsy and seizure