Selinsky high yield

Question 1

memantine

Answer 1

open channel receptor block of NMDA channels to prevent Ca+2 influx, reduce excitotoxicity, treatment for Alzheimer’s

Question 2

open channel blocker of NMDA receptors

Answer 2

memantine

Question 3

competitive inhibitor of muscarinic receptors on SA node

Answer 3

Atropine, inhibits parasymp input and keeps heart rate high, competes with ACh

Question 4

Atropine

Answer 4

competitive inhibitor of ACh at muscarinic parasympathetic receptors on SA node, keep heart rate high

Question 5

Clopidogrel

Answer 5

• pro-drug
• antiplatelet to prevent clotting post stenting
• CYP2C19 bioactivates
  
  • poor CYP2C19 metabolizers will be under anti-coagulated

Question 6

CYP2C19 polymorphism targets

Answer 6

• azepams, benzos, diazepam, flurazepam: CYP2C19 functionalizes all benzos for inactivation via glucocordination
  
  • poor CYP2C19 metabolizers will be over-dosed
• Omeprazole (proton-pump inhibitors): CYP2C19 functionalizes for inactivation
  
  • poor CYP2c19 metabolizers will be over-dosed
• clopidogrel (plavix): prodrug
  
  • poor CYP2C19 metabolizers will be under-dosed and at risk of stroke

Question 7

Tiotropium

Answer 7

• -TROPIUM
• Competitve inhibitors of ACh at Muscarinic receptors in lungs
• Prevents parasympathtic action and allows for vasodilation