Sensory processing Flashcards

(40 cards)

1
Q

What are receptor organs, and how do they work?

A
  • Organs specialized to detect a certain stimulus
  • Receptor cells within the organs convert stimuli into electrical signals
  • They are very diverse but all end up converting stimuli into neuronal input
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2
Q

What is an adequate stimulus?

A

The type of stimulus to which a sensory organ is particularly adapted
- Example –> photic energy to the eye

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3
Q

What is sensory transduction?

A

Conversion of energy from stimulus into a change in membrane potential in a receptor cell

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4
Q

What does the doctrine of specific nerve energies say?

A
  • Receptors and neural channels for different senses are independent.
  • The concept of labeled lines says that the brain recognizes distinct senses because action potentials travel along separate nerve tracts
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5
Q

What do labeled lines consist of?

A
  • Different lines for different senses
  • We can even distinguish different types of touch because we have different receptors and lines for each type
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6
Q

What does Merkerl’s disc detect?

A

Fine touch
- Small, sharp borders

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7
Q

What does Meissner’s corpuscle detect?

A

Light touch
- Small, sharp borders

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8
Q

What does the hair follicle receptor detect?

A

Touch

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9
Q

What does the Pacinian corpuscle detect?

A

Vibration and pressure

  • Large, vague borders
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10
Q

What does Ruffini’s ending detect?

A

Stretch
- Large, vague borders

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11
Q

What do free nerve endings in the epidermis detect?

A

Pain and temperature

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12
Q

How does the Pacinian corpuscle work?

A
  • Skin receptor that detects vibration and pressure
  • Stimulus opens stretch-sensitive sodium channels made of a protein called Piezo and produces a graded receptor potential
  • When it reaches the threshold and AP is generated
  • You only detect touch if the AP is generated
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13
Q

How is stimulus location detected?

A
  • From the position of the activated receptors
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14
Q

How is the intensity of sensory effects detected?

A
  • AP produced by the same sensory neurons always have the same size
  • Intensity is encoded in the number and frequency of APs
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15
Q

What does it mean that some sensory systems have neurons that specialize?

A
  • They specialize in one part of a range of intensities
  • As the strength of a stimulus increases, more neurons sensitive to higher intensities are recruited
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16
Q

What is adaptation (in terms of sensory processing)?

A

The progressive loss of response to a maintained stimulus.
Sensory systems emphasize change in stimuli, as that is more important for survival.
This prevents the NS from being overwhelmed by too much information coming in

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17
Q

What are phasic receptors?

A

They display adaptation and decrease frequency of action potentials

18
Q

What are tonic receptors?

A

Show slow or no decline in action potential frequency

19
Q

What are other ways to control information?

A
  • Accessory structures, such as eyelids
  • Top-down processing - higher brain centers suppress some sensory inputs and amplify others
20
Q

What is the dorsal column system, and how does it work?

A
  • Delivers touch information to the brain.
  • The stimulus triggers the receptive field of a neuron
  • These receptors send projections via the dorsal column of the spinal cord, where they synapse on the dorsal column nuclei in the medulla
  • Axons from neurons in the medulla cross the midline and go to the thalamus for initial processing, and then on to the primary somatosensory cortex
  • So, the brain processes touch information from the contralateral side of the body
21
Q

What is the receptive field, and how does it work?

A
  • The region in which a stimulus will alter a sensory neuron’s firing rate
  • They differ in size, shape, and responses to types of stimulation
  • To determine what touch a cortical neuron responds to, you can record from the cell and touch different parts of the body
  • The cell will fire when you touch the area it responds to
22
Q

Are receptive fields bigger in the back or finger tips?

A

Back, which is why it’s harder to distinguish between touch at two points

23
Q

What do the order and sizes of cortical representations for different regions of the skin depend on?

A

Information from the hand and fingers takes up much more room than does information from the shoulder. A larger area means more neurons; the size is not proportional to the size of the body part.

24
Q

Are cortical representations fixed?

A
  • No
  • They can be changed by experience
  • Intentional stimulation of a specific body region can expand its cortical stimulation.
  • Loss of use will cause it to shrink
  • Cells in the missing digit move to respond for other fingers –> re-organize
25
What is pain?
- An unpleasant experience associated with tissue damage - Helps us to withdraw from its source and engage in recuperative actions, and to signal others
26
What is congenital insensitivity to pain?
Inherited syndrome where the person does not experience pain
27
What are the three aspects of pain described by the McGill questionnaire?
1. Sensory-discriminative quality (e.g., throbbing, gnawing, shooting) 2. Motivational-affective (emotional) quality (e.g., tiring, sickening, fearful) 3. Cognitive evaluative quality (e.g., no pain, mild, excruciating)
28
Why is pain so hard to measure?
- Subjective - You can't see it - Cultural and societal pressures
29
What are nociceptors?
- They are peripheral receptors (or free nerve endings) that respond to painful stimuli - Located in the dermis - Have specialized receptor proteins on the cell membrane that respond to various signals - The free nerve endings produce different receptor proteins, so they respond to different stimuli like temperature changes, chemicals, and pain
30
How does peripheral mediation of pain work?
1) Damaged cells release substances that excite free nerve endings that function as nociceptors 2) AP generated in the periphery can reflexively excite blood vessels and mast cells to produce inflammation 3) Stimulated mast cells release histamine and chloroquine-like signals 4) Information enters through the dorsal root and synapses on neurons in the dorsal horn 5) Pain fibers release glutamate as a transmitter and substance P as a neuromodulator in the spinal cord. The dorsal horn cells then send information across the midline and up to the thalamus.
31
What system transmits the sensations of pain and temperature?
- Anterolateral (or spinothalamic) system
32
What happens to pain information before ascending to the brain?
It crosses the midline in the spinal chord
33
In what area of the brain are the pain signals processed?
Periaqueductal gray
34
Are pain, temperature, and itch nerves myelinated or unmyelinated?
Unmyelinated - slower conduction for less localized sensation
35
What is neuropathic (or phantom limb) pain?
- Due to the inappropriate signaling of pain by neurons. - Microglial cells release chemicals that make the dorsal horn neurons hyperexcitable and cause chronic pain - Difficult to treat, one way uses visual stimulation
36
What brain area does the feeling of social rejection activate?
- Anterior cingulate cortex. - More rejection means more activation. - Those facing social rejection claimed to feel less pain when taking an analgesic, and they also showed less activation of the ACC
37
Define Analgesia, opioids, and opiates
Analgesia - The absence or reduction in pain sensation Opioids - endogenous opiate-like peptide in the brain Opiates - Drugs that reduce pain
38
What are the three kinds of endogenous opioids?
- Endorphins - Enkephalines - Dynorphins
39
Stimulation of which opioid receptors causes a greater reduction of pain in men?
Mu
40
Stimulation of which opioid receptors causes a greater reduction of pain in women?
K