Sepsis

Question 1

Definition of sepsis

Answer 1

1. Systemic inflammation with known source of infection
2. Respiratory alkalosis
3. Hypoxemia
4. Abnormal WBC count
5. Increased CRP
6. Increased IL-6
7. Increased procalcitonin (PCT)
8. Increased lactate
9. Hyperglycemia
10. Altered coagulation parameters
11. Thrombocytopenia
12. Hyperbilirubinemia

Question 2

SIRS

Answer 2

Systemic inflammation without an infectious source is called systemic inflammatory response syndrome

Question 3

Severe sepsis definition

Answer 3

Sepsis with organ dysfunction

Question 4

Catheter related sepsis

• How to document
• most common agent

Answer 4

Documentation:

Drawing peripheral blood and catheter blood cultures:

• Catheter specimen quantitative colony count should be 5X higher than peripheral venipuncture OR
• time to positivity must be at least 2 hours sooner OR
• Identical isolates from culture tip and peripheral blood is supportive evidence

Most common agent: coagulase negative staph (S epidermidis)

Question 5

Neonatal sepsis

• Lab test
• Causative agents

Answer 5

Labs:

• band count (unreliable though)

Agents:

1. E coli
2. GBS