Which five HT antagonist increases appetite and it’s useful in carcinoid and post gastrectomy dumping syndrome
Cyproheptadine
Name a 5 HT2A Antagonist in alpha-1 blocker that has antihypertensive effect
Ketanserin
Which 5HT3 receptor antagonist are used as an anti-emetics
- Ondansetron
- granisetron
What are the uses of serotonin antagonist
- Migraine
- sedation
- anticholinergic
- anti-hypertensive
- anti-emetic
- used in schizophrenia
- postpartum haemorrhage
- parkinsonism
- galactorrhea
Which drugs can be used to treat acute attacks of migraine
- Nonsteroidal anti-inflammatory drugs (NSAIDs) - paracetamol, Aspirin, ibuprofen, diclofenac
- Anti-emetics - Metoclopramide, domperidone, prochlorperazine, promethazine
- Ergot preparation - ergotamide, Dihydroergotamine
- Triptans
What is the mechanism of action of Ergotamide
Partial agonist 5HT1B/1D receptors in Cranial blood vessels. Construction of dilated blood vessels and decreases inflammatory and extravasation of plasma in to perivascular space.
What chemical increases ergotamide absorption
Caffeine
What is the mechanism of action of triptan
Selective 5HT1B/1D agonist. Construct dilated cranial blood vessels and arterial venous shunt. Inhibit extravasation of plasma proteins in the perivascular space.
Inhibit the release of inflammatory peptides from nerve ending in the perivascular space to decrease inflammation
Name triptans
- Sumatriptan
- RizaTripton
- Eletriptan
- Naratriptan
- FrovaTriptan
What are the adverse effects of Triptans
- Paraesthesia
- tightness in the chest
- flushing, dizziness, nausea
- pain at the side of injection
- rise in BP and coronary vasospasm
What are the contraindications of Triptans
- Pregnancy
- patients with ischaemic heart disease
- peripheral vascular disease
- hypertension
- in patients with risk factor for coronary artery disease
Which drugs are used for the prophylaxis of migraine
ABCD
1.  Anticonvulsants
2. Beta blockers
3. calcium channel blockers
4. Antidepressants (tricyclic)
5. Other - methysergide and cyprohepatadine
