What are organisational effects
* permanent
what are activantional effects
what are the types of hormone action
organisational and activational effects
What is sexual dimorphisms
(differences in anatomy, physiology and behaviour between males and females)
what does Sexual differentiation in mammals depend on
organisational effects of hormones during development
where is DNA present
DNA is present in the nucleus of every cell (except red blood cells)
How many pairs of autosomes do humans have
22
what is an autosome
doesnt determmine sex differneces
Gametes are haploid… meaning…
just one copy of each chromosome
Gametes fuse to create
diploid offspring
What is gonadal
Undifferentiated ‘primordial’ gonads (yet to develop sex characteristics)
what does SRY stand for
sex-determining region Y gene
What happens to the ovary in early embryonic development
what hormone is produced in the testes that leads to mascullinises internal genitalia
Anti-mullerian hormone (AMH)
what is testosterone
• steroid hormone fat-soluble, passes readily through cell membrane • primary androgen • synthesised by Leydig cells in testes • Sertoli cells produce AMH
what does 5-alpha-reductase do
Testosterone is converted DHT. This is catalysed by enzyme 5-alpha-reductase. Females also have this enzyme but no testosterone to convert to DHT. DHT is a more potent form of testosterone.
what does genotypic sex determine
gonadal sex
what does gonadal sex determine
phenotypic sex
what does AMH leadto
internal genitalia
what does DHT lead to
external genitalia
what does testosterone lead to
rest of body
what does Further organisational effects of hormones at puberty lead to
What do homicide rates show
What was found with female guinea pigs wth testosterone
Female guinea pigs treated with testosterone when pregnant produce defeminised, masculinised daughters with male-typical behaviour