1
Q
what is syndrome of inappropriate ADH secretion characterised by?
A
hyponatraemia secondary to the dilutional effects of excessive water retention
2
Q
what are the malignancy causes of SIADH?
A
- small cell lung cancer
- pancreas
- prostate
3
Q
what are the neurological causes of SIADH?
A
- stroke
- subarachnoid haemorrhage
- subdural haemorrhage
- meninigitis/encephalitis/abscess
4
Q
what are the infective causes of SIADH?
A
- tuberculosis
- pneumonia
5
Q
what are the drug causes of SIADH?
A
- sulfonylureas
- SSRIs and tricyclics
- carbamazepine
- vincristine
- cyclophosphamide
6
Q
what are the other (e.g not malignancy, neurological, infective or drug) causes of SIADH?
A
- positive end-expiratory pressure (PEEP)
- porphyrias
7
Q
what is important to consider when correcting hyponatraemia?
A
correction must be done slowly to avoid precipitating central pontine myelinolysis
8
Q
how is SIADH managed?
A
- fluid restriction
- demeclocycline
- ADH (vasopressin) receptor antagonists
9
Q
how does demeclocycline work?
A
reduces the responsiveness of the collecting tubule cells to ADH
endocrine
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