Side Effects

Question 1

4 drugs

with the potential side effect:

Flushing

Answer 1

• Vancomycin (red man syndrome)
• Niacin
• Adenosine
• Dihydropyridine CCB’s

Question 2

4 drugs

with the potential side effect:

Coronary Vasospasm

Answer 2

• Cocaine
• Amphetamines
• Triptans (like sumatriptan)
• Ergotamine

Question 3

2 drugs

with the potential side effect:

Dilated Cardiomyopathy

Answer 3

• Doxoruvicin
• Daunorubicin

Question 4

6 drugs

with the potential side effect:

Torsades de pointes

Answer 4

• Potassium Channel Blockers (class III)
• Sodium Channel Blockers (Class 1A)
• Macrolides
• Haloperidol
• Chloroquine
• Protease inhibitors

Question 5

2 drugs

with the potential side effect:

Thrombocytopenia

Answer 5

• Heparin (HIT)
• Cimetidine (H2 Blocker)

Question 6

6 drugs

with the potential side effect:

Agranulocytosis

Answer 6

• Clozapine
• Carbamazepine
• Colchicine
• Propylthiouracil (PTU)
• Methimazole
• Dapsone

Question 7

5 drugs

with the potential side effect:

Aplastic anemia

Answer 7

• Chloramphenicol
• Benzene
• NSAIDs
• Propylthiouracil (PTU)
• Methimazol

Question 8

1 drug

with the potential side effect:

Gray Baby Syndrome

Answer 8

• Chloramphenicol

Question 9

9 drugs

with the potential side effect:

Hemolysis in G6PD Deficiency

Answer 9

• Isoniazid
• Sulfonamides
• Primaquine
• Aspirin (high-dose)
• Ibuprofen
• Nitrofurantoin (UTI drug)
• Dapsone
• Fava beans
• Naphthalene

Question 10

1 major drug

with the potential side effect:

Thrombosis

Answer 10

• Oral Contraceptives (especially if a smoker and/or over 35)

Question 11

3 drugs

with the potential side effect:

Pulmonary fibrosis

Answer 11

• Amiodarione (LFT’s, PFT’s, TFT’s)
• Bleomycin (anticancer)
• Busulfan (anticancer)

Question 12

1 major drug

with the potential side effect:

Cough

Answer 12

• ACE inhibitors (increase in bradykinin is the cause; substitute for ARB’s which don’t increase bradykinin if this is an issue)

Question 13

3 drugs

with the potential side effect:

Pseudomembranous colitis

Answer 13

• Clindamycin
• Amoxicillin
• Ampicillin

Question 14

4 drugs

with the potential side effect:

Hepatic necrosis

Answer 14

• Halothane
• Acetaminophen
• Valproic acid
• Amanita phalloides (mushroom toxin)

Question 15

1 major drug

with the potential side effect:

Hepatitis

Answer 15

• Isoniazid

Question 16

1 drug

with the potential side effect:

Tertiary adrenal insufficiency

Answer 16

• Corticosteroid withdrawal (pt dependent on exogenous steroids)

Question 17

7 drugs

with the potential side effect:

Gynecomastia

Answer 17

STACKED

• Spironolactone
• Digoxin
• Estrogens
• Cimetidine
• Alcohol (chronic use)
• Ketoconazole
• Marijuana (THC)

Question 18

2 drugs

with the potential side effect:

Hot flashes

Answer 18

• Tamoxifen
• Clomiphene

Question 19

3 drugs

with the potential side effect:

Hypothyroidism

Answer 19

• Amiodarone
• LIthium
• Sulfonamides

Question 20

4 drugs

with the potential side effect:

Gout

Answer 20

• Diuretics (loop and Thiazide)
• Niacin
• Cyclosporine
• Pyrazinamide

Question 21

2 drugs

with the potential side effect:

Gingival hyperplasia

Answer 21

• Phenytoin
• Verapamil

Question 22

2 drugs

with the potential side effect:

Osteoporosis

Answer 22

• Corticosteroids
• Heparin

Question 23

3 drugs

with the potential side effect:

Photosensitivity

Answer 23

SAT for a Photo

• Sulfonamides
• Amiodarone
• Tetracycline

Question 24

8 drugs

with the potential side effect:

Stevens-Johnson syndrome

Answer 24

CLAPPPERS (R is Rash)

• Carbamazepine (antiseizure drug)
• Lamotrigine (antiseizure drug)
• Allopurinol
• Phenytoin (antiseizure drug)
• Phenobarbital (antiseizure drug)
• Penicillin
• Ethosuxamide (antiseizure drug)
• Sulfa Drugs

Question 25

5 drugs with the potential side effect: **Drug induced lupus**

Answer 25

SHIPP * Sulfonamides * Hydralazine * Isoniazid * Procainamide * Phenytoin

Question 26

1 drug with the potential side effect: **Tendinitis/cartilage damage**

Answer 26

* Fluoroquinolones

Question 27

3 drugs with the potential side effect: **Interstitial Nephritis**

Answer 27

* NSAIDs * Furosemide * Antibiotics

Question 28

2 drugs with the potential side effect: **Diabetes insipidus**

Answer 28

* Lithium * Demeclocycline

Question 29

3 drugs with the potential side effect: **Fanconi syndrome**

Answer 29

* Tetracycline (EXPIRED) * Heavy metal exposure * Wilsons Disease

Question 30

2 drugs with the potential side effect: **Hemorrhagic cystitis**

Answer 30

* Cyclophosphamide * Ifosfamide

Question 31

3 drugs with the potential side effect: **Parkinson-like syndrome**

Answer 31

* Metaclopramide * Antipsychotics * Reserpine

Question 32

2 drugs with the potential side effect: **Cinchonism**

Answer 32

* Quinidine * Quinine

Question 33

8 drugs with the potential side effect: **Seizures**

Answer 33

* Buproprion * Imipenem * Cilastatin * Isoniazid * Tramadol * Metoclopramide * Benzodiazepine withdrawal * Alcohol withdrawal

Question 34

2 drugs with the potential side effect: **Tardive Dyskinesia**

Answer 34

* Antipsychotics * Metoclopramide

Question 35

5 drugs with the potential side effect: **Disulfiram-like reaction**

Answer 35

* Metronidazole * Certain Cephalosporins * Procarbazine * First Generation Sulfonylureas * Disulfiram

Question 36

3 drugs with the potential side effect: **Nephrotoxicity + Neurotoxicity**

Answer 36

* Aminoglycosides * Cisplatin * Polymixins

Question 37

4 drugs with the potential side effect: **Nephrotoxicity + Ototoxicity**

Answer 37

* Aminoglycosides * Vancomycin * Loop diuretics * Cisplatin

Question 38

5 drugs with the potential side effect: **Anticholinergic effects**

Answer 38

* Atropine * TCA's * H1 Blockers (Diphenhydramine) * Thioridazine (Low potency neuroleptic) * Chlorpromazine (Low potency neuroleptic)