Signalling Flashcards by Ellie Ted

Q

What does TLR2 target?

A

grave +ve bacteria

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Q

What does TLR3 target?

A

Viruses

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Q

What does TLR4 target?

A

Gram -ve bacteria

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Q

What does TLR3 target?

A

dsRNA in endosome

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Q

Whats special about TLR3?

A

TIR independant pathway, doesnt use MyD88 uses TRIF

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Q

What does TRIF activate?

A

INF, IRF3 and NFkB.

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Q

What does dectin-1 target?

A

fungi

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Q

What receptors do Dectins recognise?

A

beta-glycans and zymoson carbohydrate polymers

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Q

What are viral receptors?

A

RIG-I

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Q

What are intracellular bacteria receptors?

A

Nod1/2

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