SJS/TEN

Question 1

Describe Stevens-Johnson syndrome or Toxic Epidermal Necrolysis

Answer 1

It is life-threatening exfoliative mucocutaneous disease

Question 2

Epidermal separation of SJS and TEN

Answer 2

SJS = <10% of body surface area
TEN = >30% of body surface area

Question 3

Features of SJS

Answer 3

Mucosal lesions
Epidermal separation
Fever
Skin tenderness

Question 4

Features of TEN

Answer 4

Mucosal lesions
Epidermal separation
Fever
Skin tenderness
Hypotension
Decreased consciousness

Question 5

Biopsy of SJS/TEN

Answer 5

SJS = Degeneration of basal layer of the epidermis
TEN = Full-thickness eosinophilic epidermal necrosis

Question 6

How to treat SJS/TEN?

Answer 6

Short course of intravenous immunoglobulin (IVIG)