Sketchy - Daptomycin

Question 1

Spectrum: Daptomycin

Answer 1

Gram pos - Staph, Strep, Enterococcus

Question 2

MOA: Daptomycin

Answer 2

Inserts tail into bacterial cell wall –> depolarization of cell and death
Bacteriocidal

Question 3

When is daptomycin used?

Answer 3

When there is resistance to vancomycin ie Enterococcus (UTI, GI) and vanco-resistant MRSA

Question 4

Staph endocarditis is effectively treated with Vanco or:

Answer 4

Daptomycin

Question 5

Why is Daptomycin not recommended for treating pneumonia?

Answer 5

It is antagonized by pulmonary surfactant

Question 6

Adverse effects: Daptomycin

Answer 6

Myopathy, rhabdomyolysis

Monitor Creatinine phosphokinase levels