SLE

Question 1

1. SLE is more common in:
   a. Female infants
   b. Male infants
   c. Adolescent through middle-aged women
   d. Adolescent through middle-aged men

Answer 1

c. Adolescent through middle-aged women

Question 2

2. One of the most potent inducers of abnormalities and
   clinical manifestations of SLE is:
   a. Chloramphenicol
   b. Procainamide hydrochloride
   c. Isoniazid
   d. Penicillin

Answer 2

b. Procainamide hydrochloride

Question 3

3. The cellular aberrations in SLE include:
   a. B cell depletion
   b. Deficiency of suppressor T cell function
   c. Hyperproduction of helper T cells
   d. Both b and c

Answer 3

d. Both b and c

Question 4

4. The principal demonstrable antibody in SLE is
   antibody to:
   a. Nuclear antigen
   b. Cell surface antigens of hematopoietic cells
   c. Cell surface antigens to neuronal cells
   d. Lymphocytic leukocytes

Answer 4

a. Nuclear antigen

Question 5

5. The sites of immune complex deposition in SLE are
   influenced by all the following factors except:
   a. Molecular size
   b. Molecular configuration
   c. Immune complex specificity
   d. Immunoglobulin class

Answer 5

c. Immune complex specificity

Question 6

6. Renal disease secondary to SLE can be assessed by:
   a. Antibody to native dsDNA
   b. Levels of C3 and C4
   c. Levels of ANA
   d. All of the above

Answer 6

d. All of the above

Question 7

7. SLE is a classic model of autoimmune disease and
   is a(n):
   a. Abnormality of the joints
   b. Systemic rheumatoid disorder
   c. Abnormality of connective tissue
   d. All of the above

Answer 7

d. All of the above

Question 8

8. The overall incidence of SLE has an increased frequency
   among:
   a. Blacks
   b. Native Americans
   c. Puerto Ricans
   d. All of the above

Answer 8

d. All of the above

Question 9

9. Patients with SLE characteristically manifest:
   a. Butterfly rash over the bridge of the nose
   b. Skin lesions on the arms and legs
   c. Ulcerations on the trunk
   d. Photophobia

Answer 9

a. Butterfly rash over the bridge of the nose

Question 10

10. Laboratory features of SLE include:
    a. The presence of ANAs
    b. Circulating anticoagulant and immune complexes
    c. Decreased levels of complement
    d. All of the above

Answer 10

d. All of the above

Question 11

11. Laboratory procedures that are helpful in assessing renal
    disease include:
    a. Antibody to double-stranded DNA
    b. Levels of C3 and C4
    c. Cryoglobulin assay
    d. All of the above

Answer 11

d. All of the above

Question 12

12. Antinuclear antibodies (ANAs) are always indicative
    of SLE.
    a. True
    b. False

Answer 12

b. False

Question 13

13-16. Match the appropriate antibody and disease.
13. _______ Jo-1
14. _______ Mi-I
15. _______ SS-B/La
16. _______ RANA
a. Systemic lupus erythematosus
b. Dermatomyositis
c. Progressive systemic sclerosis
d. Polymyositis

Answer 13

13. d
14. b
15. a
16. c

Question 14

17 and 18. Match the interpretation of the ANA staining
pattern to its respective antibody.
17. _______ Diffused or homogeneous pattern
18. _______ Speckled pattern
a. Anti–DNA-nucleoprotein antibody
b. Antibody to nucleolar RNA
c. Antibody to any extractable nuclear antigen devoid
of DNA or histone
d. Anticentromere antibody

Answer 14

17. a
18. c