Describe the direction of DNA replication
3’ -> 5’ of TEMPLATE strand
5’ -> 3’ of new strand
Helicase function
Unwind DNA
Define mutation
Permanent change in DNA. Ultimate source of all genetic variation
Which enzyme has proof reading activity?
DNA polymerase (III)
Some genetic diseases cause errors in proof reading mechanisms. Name two
Lynch syndrome (colon cancer), Xeroderma pigmentosum
Which of the two mutations are passed onto future generations?
Gametic or Somatic
Gametic (during DNA replication in meiosis)
Name two autosomal dominant and two autosomal recessive disease discussed in class
Dominant: Huntington’s disease, Williams Syndrome
Recessive: Cystic fibrosis, Tay-Sachs disease