SMPC Flashcards

(4 cards)

0
Q

Contra Indications

A
Severe renal
Moderate and Severe hepatic
Potent cyp3a inhibitors
Anti fungals itraconazole, ketraconazole
Class 1a (quinidine) and class 3 Anti Arrythmics (Soltalol Dofetilide) but not Amiodarone.
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1
Q

Licence
Doses
Cost

A

375,500,750 bd

£48.98

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2
Q

Clinical Trials

Carisa

A
CARISA 2004 JAMA CHAITMAN
N=823 12 wk study
3 arms Placebo, Ranexa 750bd,Ranexa1000bd
Efficacy on top of
Amlodopine Diltiazem or Atenolol

Primary - excersise
Secondary - reduction angina attacks

4.3 to 2.5 p value 0.006

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3
Q

Khan audit refractory angina pts

Retrospective audit wales

A
N=25
18 of 25 male
Mean age 67 range 49-93
CCS class
2 4pts
3 11tpts
4 8 pts
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