Contra Indications
Severe renal Moderate and Severe hepatic Potent cyp3a inhibitors Anti fungals itraconazole, ketraconazole Class 1a (quinidine) and class 3 Anti Arrythmics (Soltalol Dofetilide) but not Amiodarone.
Licence
Doses
Cost
375,500,750 bd
£48.98
Clinical Trials
Carisa
CARISA 2004 JAMA CHAITMAN N=823 12 wk study 3 arms Placebo, Ranexa 750bd,Ranexa1000bd Efficacy on top of Amlodopine Diltiazem or Atenolol
Primary - excersise
Secondary - reduction angina attacks
4.3 to 2.5 p value 0.006
Khan audit refractory angina pts
Retrospective audit wales
N=25 18 of 25 male Mean age 67 range 49-93 CCS class 2 4pts 3 11tpts 4 8 pts