6 years child with goiter.. first thing to come into ur mind ?
Dyshormonogenesis
What is goiter?
Generalized enlargement of thyroid gland
Dx of simple goiter clinically?
By exclusion
Early malignancy is confusing with simple so whats the next step?
Have to do investigations to confirm
What are the types of goiter? Statistically?
2 important things in every cancer u check clinically ?
LN and fixation
Goiter with weight loss?
Neoplastic
Goiter with pain?
Inflammatory
Goiter with palpation and tremor?
Toxic goiter
MC goiter is ?
Simple goiter
Thyroid hormones in simple goiter is ?
Normal euthyroid
Etiology of simple goiter?
Due to stimulation of thyroid gland may increase
Simple goiter is divided into ?
According to surface
Diffuse (mainly medical ttt)
Nodular (surgical ttt)
Why to study simple diffuse goiter when ttt is medical?
Cause it’s a PDF to nodular goiter
Most important of simple goiter?
Iodine deficiency ( increase demand or decrease intake)
What is pendred syndrome?
Due to peroxidase enzyme deficiency
Goitreous agents?
2. Drugs PASA and antithyroid
Types of simple goiter?
Cause of endemic goiter ?
Deficient intake of iodine in food
Daily intake of iodine should be?
0.1 to 0.15 mg/day
ttt of physiological goiter is?
No ttt in mild cases, small dose thyroxin can be given
the most common thyroid disease is ?
SNG
Cause of SNG?
Unknown so theory.. repeated fluctuation of TSH level
Recurrent hyperplasia hypervascularity and He
PDF of SNG?
Diffuse goiter – nodular ( iodine deficiency )