Solid Vs Solution Comb

Question 0

Which has wide range of quantity?

Answer 0

Solution - y

Solid - no

Question 1

Which has wide rage of chem?

Answer 1

Solution - yes

Solid - limited, some reactions don’t work well in solid & the first building block must attach to the solid support

Question 2

Advantages of solid phase? 4

Answer 2

Automation
‘Pooling’ - high cap for mixtures
Good purity
Easy to drive reaction to completion (use excess)

Question 3

Disadvantages of solid? 4

Answer 3

Cleavage step
Large no of steps
(Chem and quantities limited)

Question 4

Advantages of solution? 4(+2)

Answer 4

High capacity for discretes 
Direct link to screening 
Simple to perform 
Efficient for short sequences
(Better amounts and chem avail)

Question 5

Disadvantages of solution2

Answer 5

Need to be optimised to work effectively

Limit purification - effects final product