Carbapenem (P) (Needs to be paired with Cilastatin to inhibit dehydropeptidase) _G+:_ Staph (not MRSA) Strep (including PRSP) Listeria Enterococcus _G-:_ H. Influ Neisseria Enterobacteriaceae Pseudomonas Acinetobacter _Anaerobes:_ Most (except C diff) _SMAC are RESISTANT_ Spirochete, MRSA, Atypicals, C diff

Carbapenem (P) _G+:_ Staph (not MRSA) Strep (including PRSP) Listeria Enterococcus _G-:_ H. Influ Neisseria Enterobacteriaceae Pseudomonas Acinetobacter _Anaerobes:_ Most (except C diff) _SMAC are RESISTANT_ Spirochete, MRSA, Atypicals, C diff

Carbapenem (P) _G+:_ Staph (not MRSA) Strep (including PRSP) Listeria _G-:_ H. Influ Neisseria Enterobacteriaceae _Anaerobes:_ Most (except C diff) _SMAC APE are RESISTANT_ Spirochete, MRSA, Atypicals, C diff, Acinetobacter, Pseudomonas, Enterococcus

Monobactam (P) G- (ONLY): Pseudomonas Serratia Enterobacteriaceae Alternative for AG's in G- infections NO GRAM POS OR ANAEROBE ACTIVITY

Vancomycin (P) (ORAL FORMULATION FOR C DIFF) Bacteriocidal: Prevent Transglycosylation and subsequent transpeptidation reaction G+: MRSA VRSA (w/ an aminoglycoside) PRSP (w/ a G3 Cephalosporin) Enterococci (NOT VRE) Anaerobes: C diff (GIVEN ORALLY FOR THIS)

Aminoglycoside Reserved for organisms resistant to other AGs (more resistant to drug modifying enz) _G+:_ MRSA Listeria (w/ Ampicillin) Streptococcus _G-:_ Pseudomonas (w/ piperacillin) Enterobacteriaceae H Influenza Mycobacteria (MDR- TB) (better than Genta or Tobra) INEFECTIVE AGAINST ANAEROBES and ENTEROCOCCI

Aminoglycoside _G+:_ Enterococci (w/B-Lac or Vanc) MRSA (w/ Vancomycin) Listeria (w/ Ampicillin) Streptococcus _G-:_ Pseudomonas (+ piperacillin) Enterovacteriaceae H Influenza Mycobacteria:various _INEFFECTIVE AGAINST ANAEROBES_

Aminoglycoside Least toxiv but also least active against G- and resistance is developed quickly _G+:_ Enterococci _G-:_ Francisella Tularensis Yersinia Pestis Brucellosis Mycobacterial TB _INEFFECTIVE AGAINST ANAEROBES AND PSEUDOMONAS_

Tetracyclines (O) (food decreases absorption) Broad Spectrum Bacteriostatic: reversibly binds to the a site of 3Os inhibiting ELONGATION Absorption is decreased by Polyvalent cations _G+:_ Streptococcus (PRSP Staphylococcus (CA-MRSA) Enterococcus Listeria _G-:_ H. Influenza Neisseria Meningitides Enterobacteriaceae _Anaerobes:_ Most (except C. Diff) PROPRIONIBACTERIUM (ACNE) _Biological Warfare:_ Brucellosis Y Pestis F. Tularensis (w/ an aminoglycoside Bacilus anthracis _Spirochetes:_ Treponema Pallidum Borrelia Burgdorferi _Atypicals_ Mycoplasma Pneumonia Chlamydia Trachomatis Erlichia _Rickettsiae:_ RMSF _Mycobacteria:_ Mycobacteria (TB, M. Leprae) PSEUDOMONAS AERUGINOSA (HAS INTRINSIC RESISTANCE)

Tetracyclines (O,P) (Hepatic) (Food does NOT decrease absorption) Broad Spectrum Bacteriostatic: reversibly binds to the a site of 3Os inhibiting ELONGATION Absorption is decreased by Polyvalent cations _G+:_ Streptococcus (PRSP Staphylococcus (CA-MRSA) Enterococcus Listeria _G-:_ H. Influenza Neisseria Meningitides Enterobacteriaceae _Anaerobes:_ Most (except C. Diff) PROPRIONIBACTERIUM (ACNE) _Biological Warfare:_ Brucellosis Y Pestis F. Tularensis (w/ an aminoglycoside Bacilus anthracis _Spirochetes:_ Treponema Pallidum Borrelia Burgdorferi _Atypicals_ Mycoplasma Pneumonia Chlamydia Trachomatis Erlichia _Rickettsiae:_ RMSF _Mycobacteria:_ Mycobacteria (TB, M. Leprae) PSEUDOMONAS AERUGINOSA (HAS INTRINSIC RESISTANCE)

Tetracyclines (O,P) (food does NOT decrease absorption) Broad Spectrum Bacteriostatic: reversibly binds to the a site of 3Os inhibiting ELONGATION Absorption is decreased by Polyvalent cations _G+:_ Streptococcus (PRSP Staphylococcus (CA-MRSA) Enterococcus Listeria _G-:_ H. Influenza Neisseria Meningitides Enterobacteriaceae _Anaerobes:_ Most (except C. Diff) PROPRIONIBACTERIUM (ACNE) _Biological Warfare:_ Brucellosis Y Pestis F. Tularensis (w/ an aminoglycoside Bacilus anthracis _Spirochetes:_ Treponema Pallidum Borrelia Burgdorferi _Atypicals_ Mycoplasma Pneumonia Chlamydia Trachomatis Erlichia _Rickettsiae:_ RMSF _Mycobacteria:_ Mycobacteria (TB, M. Leprae) PSEUDOMONAS AERUGINOSA (HAS INTRINSIC RESISTANCE)

Tetracyclines (P) (Biliary) Broad Spectrum Bacteriostatic: reversibly binds to the a site of 3Os inhibiting ELONGATION BUT IT BINDS WITH 5X THE AFFINITY OF TETS Additional coverage to tetracyclines PRSP MRSA (CA+HA) VRSA VRE SAME AS TETRACYCLINES BELOW _G+:_ Streptococcus (PRSP Staphylococcus (CA-MRSA) Enterococcus Listeria _G-:_ H. Influenza Neisseria Meningitides Enterobacteriaceae _Anaerobes:_ Most (except C. Diff) PROPRIONIBACTERIUM (ACNE) _Biological Warfare:_ Brucellosis Y Pestis F. Tularensis (w/ an aminoglycoside Bacilus anthracis _Spirochetes:_ Treponema Pallidum Borrelia Burgdorferi _Atypicals_ Mycoplasma Pneumonia Chlamydia Trachomatis Erlichia _Rickettsiae:_ RMSF _Mycobacteria:_ Mycobacteria (TB, M. Leprae) PSEUDOMONAS AERUGINOSA (HAS INTRINSIC RESISTANCE)

Macrolides (absorption dec by food) (all macrolides billiary) Bacteriostatic: Binds 50S and blocks translocation (macro slide prevents sliding) G+: Staphylococcus (NOT MRSA) Streptococcus (NOT PRSP) C diptheria G-: Neisseria Meningitidis Bordetella Pertussis Campylobacter H. INfluenza Atypicals: Chlamydia Mycoplasma Pneumonia Legionella Pneumophillia Rickettsieae Spirochetes: Treponema Pallidum Borrelia Burgdorferi Anaerobes: PROPRIONIBACTERIUM All (EXCEPT C DIFF)

Macrolides (absorption dec by food) (all macrolides billiary) Bacteriostatic: Binds 50S and blocks translocation (macro slide prevents sliding) ERythro (seen below) Plus Moraxella MAC G+: Staphylococcus (NOT MRSA) Streptococcus (NOT PRSP) C diptheria G-: Neisseria Meningitidis Bordetella Pertussis Campylobacter H. INfluenza Atypicals: Chlamydia Mycoplasma Pneumonia Legionella Pneumophillia Rickettsieae Spirochetes: Treponema Pallidum Borrelia Burgdorferi Anaerobes: PROPRIONIBACTERIUM All (EXCEPT C DIFF)

Macrolides (absorption IS DELAYED BY FOOD NOT DEC) (all macrolides billiary) Bacteriostatic: Binds 50S and blocks translocation (macro slide prevents sliding) ERythro (seen below) Plus Moraxella MAC H Pylori (w/ amoxicillin and omeprazole) G+: Staphylococcus (NOT MRSA) Streptococcus (NOT PRSP) C diptheria G-: Neisseria Meningitidis Bordetella Pertussis Campylobacter H. INfluenza Atypicals: Chlamydia Mycoplasma Pneumonia Legionella Pneumophillia Rickettsieae Spirochetes: Treponema Pallidum Borrelia Burgdorferi Anaerobes: PROPRIONIBACTERIUM All (EXCEPT C DIFF)

Lincosamide (absorption not affected by food) (Unchanged when renally excreted) Bacteriostatic: binds 50S to block Initiation complex AND block translocation step G+: Streptococcus (PRSP) Staphylococcus (CA-MRSA) Anaerobes: MOST (EXCEPT C DIFF) NO GRAM NEGATIVE EFFECT DUE TO INEFFICIET PORIN PENETRATION

Spectrums Flashcards by Austin Flick

Imipenem

Carbapenem (P) (Needs to be paired with Cilastatin to inhibit dehydropeptidase)

G+:

Staph (not MRSA)
Strep (including PRSP)
Listeria
Enterococcus

G-:

H. Influ
Neisseria
Enterobacteriaceae
Pseudomonas
Acinetobacter

Anaerobes:

Most (except C diff)

SMAC are RESISTANT

Spirochete, MRSA, Atypicals, C diff

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Meropenem

Carbapenem (P)

G+:

Staph (not MRSA)
Strep (including PRSP)
Listeria
Enterococcus

G-:

H. Influ
Neisseria
Enterobacteriaceae
Pseudomonas
Acinetobacter

Anaerobes:

Most (except C diff)

SMAC are RESISTANT

Spirochete, MRSA, Atypicals, C diff

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Ertapenem

Carbapenem (P)

G+:

Staph (not MRSA)
Strep (including PRSP)
Listeria

G-:

H. Influ
Neisseria
Enterobacteriaceae

Anaerobes:

Most (except C diff)

SMAC APE are RESISTANT

Spirochete, MRSA, Atypicals, C diff, Acinetobacter, Pseudomonas, Enterococcus

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Aztreonam

Monobactam (P)

G- (ONLY):

Pseudomonas
Serratia
Enterobacteriaceae

Alternative for AG’s in G- infections

NO GRAM POS OR ANAEROBE ACTIVITY

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Vancomycin

Vancomycin (P) (ORAL FORMULATION FOR C DIFF)

Bacteriocidal: Prevent Transglycosylation and subsequent transpeptidation reaction

G+:

MRSA
VRSA (w/ an aminoglycoside)
PRSP (w/ a G3 Cephalosporin)
Enterococci (NOT VRE)

Anaerobes:

C diff (GIVEN ORALLY FOR THIS)

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Televancin

Televancin (P) (reserve for resistant gram positives)

Bacteriocidal: Like vancomycin (prevents transglycosylation) but also disrupts bacterial membane

G+:

MRSA
VRSA
VRE
PRSP

Anaerobes:

C Diff
*

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Bacitracin

Bacitracin (T) (often combined with Neomycin or Polymixin topically)

Topically for Skin and Occular (Oral for C Diff Colitis RARELY)

Block step 2 of CWS with Blocking Bactoprenol Phosphate

G+:

Streptococcus
Staphylococcus
Enterococcus (INCLUDING VRE)

G-:

Some

Anaerobes:

ALL (INCLUDING C DIFF)

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Fosfomycin

Fosfomycin (O)

Similar to Phosphoenolpyruvate structurally; ireversibly inhibits Enolpyruvate transferase- blocks synthesis of UDP MurNAc (step 1)

Used Primarily for UTIs (good distribution to bladder, kidneys, prostate and seminal vess)

Enterobacteriaceae
Serratia
Proteus
Ecoli
Citrobacter
Klebsiella

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Tobramycin

Aminoglycoside (poorly absorbed in stomach and intestines) (more expensive then Genta)

Bactericidal: Irreversible binding to the 30S subunit to inhibit INITIATION

Reserved for serious G- infections resistant to less toxic drugs (Aminoglycosides have best action against aerobic gram - but are also often more toxic)

G+:

MRSA (w/ Vancomycin)
Listeria (w/ Ampicillin)
Streptococcus

G-:

Pseudomonas (w/ piperacillin)
Enterobacteriaceae
H Influenza
Mycobacteria

INEFECTIVE AGAINST ANAEROBES and ENTEROCOCCI

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Amikicin

Aminoglycoside

Reserved for organisms resistant to other AGs (more resistant to drug modifying enz)

G+:

MRSA
Listeria (w/ Ampicillin)
Streptococcus

G-:

Pseudomonas (w/ piperacillin)
Enterobacteriaceae
H Influenza
Mycobacteria (MDR- TB) (better than Genta or Tobra)

INEFECTIVE AGAINST ANAEROBES and ENTEROCOCCI

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Neomycin

Aminoglycoside (T) (Most Nephrotoxic so limited to Topical use w/ bacitracin and polymixin)

Used as PROPHYLAXIS FOR COLORECTAL SURGERY (HSR with long term use)

Gram + and Gram -

BUT NO ANAEROBES

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Gentamicin

Aminoglycoside

G+:

Enterococci (w/B-Lac or Vanc)
MRSA (w/ Vancomycin)
Listeria (w/ Ampicillin)
Streptococcus

G-:

Pseudomonas (+ piperacillin)
Enterovacteriaceae
H Influenza
Mycobacteria:various

INEFFECTIVE AGAINST ANAEROBES

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Streptomycin

Aminoglycoside

Least toxiv but also least active against G- and resistance is developed quickly

G+:

Enterococci

G-:

Francisella Tularensis
Yersinia Pestis
Brucellosis
Mycobacterial TB

INEFFECTIVE AGAINST ANAEROBES AND PSEUDOMONAS

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Tetracycline

Tetracyclines (O) (food decreases absorption)

Broad Spectrum

Bacteriostatic: reversibly binds to the a site of 3Os inhibiting ELONGATION

Absorption is decreased by Polyvalent cations

G+:

Streptococcus (PRSP
Staphylococcus (CA-MRSA)
Enterococcus
Listeria

G-:

H. Influenza
Neisseria Meningitides
Enterobacteriaceae

Anaerobes:

Most (except C. Diff)
PROPRIONIBACTERIUM (ACNE)

Biological Warfare:

Brucellosis
Y Pestis
F. Tularensis (w/ an aminoglycoside
Bacilus anthracis

Spirochetes:

Treponema Pallidum
Borrelia Burgdorferi

Atypicals

Mycoplasma Pneumonia
Chlamydia Trachomatis
Erlichia

Rickettsiae:

RMSF

Mycobacteria:

Mycobacteria (TB, M. Leprae)

PSEUDOMONAS AERUGINOSA (HAS INTRINSIC RESISTANCE)

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Doxycycline

Tetracyclines (O,P) (Hepatic) (Food does NOT decrease absorption)

Broad Spectrum

Bacteriostatic: reversibly binds to the a site of 3Os inhibiting ELONGATION

Absorption is decreased by Polyvalent cations

G+:

Streptococcus (PRSP
Staphylococcus (CA-MRSA)
Enterococcus
Listeria

G-:

H. Influenza
Neisseria Meningitides
Enterobacteriaceae

Anaerobes:

Most (except C. Diff)
PROPRIONIBACTERIUM (ACNE)

Biological Warfare:

Brucellosis
Y Pestis
F. Tularensis (w/ an aminoglycoside
Bacilus anthracis

Spirochetes:

Treponema Pallidum
Borrelia Burgdorferi

Atypicals

Mycoplasma Pneumonia
Chlamydia Trachomatis
Erlichia

Rickettsiae:

RMSF

Mycobacteria:

Mycobacteria (TB, M. Leprae)

PSEUDOMONAS AERUGINOSA (HAS INTRINSIC RESISTANCE)

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Minocycline

Tetracyclines (O,P) (food does NOT decrease absorption)

Broad Spectrum

Bacteriostatic: reversibly binds to the a site of 3Os inhibiting ELONGATION

Absorption is decreased by Polyvalent cations

G+:

Streptococcus (PRSP
Staphylococcus (CA-MRSA)
Enterococcus
Listeria

G-:

H. Influenza
Neisseria Meningitides
Enterobacteriaceae

Anaerobes:

Most (except C. Diff)
PROPRIONIBACTERIUM (ACNE)

Biological Warfare:

Brucellosis
Y Pestis
F. Tularensis (w/ an aminoglycoside
Bacilus anthracis

Spirochetes:

Treponema Pallidum
Borrelia Burgdorferi

Atypicals

Mycoplasma Pneumonia
Chlamydia Trachomatis
Erlichia

Rickettsiae:

RMSF

Mycobacteria:

Mycobacteria (TB, M. Leprae)

PSEUDOMONAS AERUGINOSA (HAS INTRINSIC RESISTANCE)

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Tigecycline

Tetracyclines (P) (Biliary)

Broad Spectrum

Bacteriostatic: reversibly binds to the a site of 3Os inhibiting ELONGATION BUT IT BINDS WITH 5X THE AFFINITY OF TETS

Additional coverage to tetracyclines

PRSP
MRSA (CA+HA)
VRSA
VRE

SAME AS TETRACYCLINES BELOW

G+:

Streptococcus (PRSP
Staphylococcus (CA-MRSA)
Enterococcus
Listeria

G-:

H. Influenza
Neisseria Meningitides
Enterobacteriaceae

Anaerobes:

Most (except C. Diff)
PROPRIONIBACTERIUM (ACNE)

Biological Warfare:

Brucellosis
Y Pestis
F. Tularensis (w/ an aminoglycoside
Bacilus anthracis

Spirochetes:

Treponema Pallidum
Borrelia Burgdorferi

Atypicals

Mycoplasma Pneumonia
Chlamydia Trachomatis
Erlichia

Rickettsiae:

RMSF

Mycobacteria:

Mycobacteria (TB, M. Leprae)

PSEUDOMONAS AERUGINOSA (HAS INTRINSIC RESISTANCE)

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Erythromycin

Macrolides (absorption dec by food) (all macrolides billiary)

Bacteriostatic: Binds 50S and blocks translocation (macro slide prevents sliding)

G+:

Staphylococcus (NOT MRSA)
Streptococcus (NOT PRSP)
C diptheria

G-:

Neisseria Meningitidis
Bordetella Pertussis
Campylobacter
H. INfluenza

Atypicals:

Chlamydia
Mycoplasma Pneumonia
Legionella Pneumophillia

Rickettsieae

Spirochetes:

Treponema Pallidum
Borrelia Burgdorferi

Anaerobes:

PROPRIONIBACTERIUM
All (EXCEPT C DIFF)

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Azitromycin

Macrolides (absorption dec by food) (all macrolides billiary)

Bacteriostatic: Binds 50S and blocks translocation (macro slide prevents sliding)

ERythro (seen below) Plus

Moraxella
MAC

G+:

Staphylococcus (NOT MRSA)
Streptococcus (NOT PRSP)
C diptheria

G-:

Neisseria Meningitidis
Bordetella Pertussis
Campylobacter
H. INfluenza

Atypicals:

Chlamydia
Mycoplasma Pneumonia
Legionella Pneumophillia

Rickettsieae

Spirochetes:

Treponema Pallidum
Borrelia Burgdorferi

Anaerobes:

PROPRIONIBACTERIUM
All (EXCEPT C DIFF)

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Clarithromycin

Macrolides (absorption IS DELAYED BY FOOD NOT DEC) (all macrolides billiary)

Bacteriostatic: Binds 50S and blocks translocation (macro slide prevents sliding)

ERythro (seen below) Plus

Moraxella
MAC
H Pylori (w/ amoxicillin and omeprazole)

G+:

Staphylococcus (NOT MRSA)
Streptococcus (NOT PRSP)
C diptheria

G-:

Neisseria Meningitidis
Bordetella Pertussis
Campylobacter
H. INfluenza

Atypicals:

Chlamydia
Mycoplasma Pneumonia
Legionella Pneumophillia

Rickettsieae

Spirochetes:

Treponema Pallidum
Borrelia Burgdorferi

Anaerobes:

PROPRIONIBACTERIUM
All (EXCEPT C DIFF)

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Clindamycin

Study These Flashcards

Lincosamide (absorption not affected by food) (Unchanged when renally excreted)

Bacteriostatic: binds 50S to block Initiation complex AND block translocation step

G+:

Streptococcus (PRSP)
Staphylococcus (CA-MRSA)

Anaerobes:

MOST (EXCEPT C DIFF)

NO GRAM NEGATIVE EFFECT DUE TO INEFFICIET PORIN PENETRATION

Chloramphenicol

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Chloramphenicol (P) (inactivated by glucuronosyl transferase host enzyme) abosrbed well in gut (last resort drug rarely used in US)

Bacteriostatic: binds to 50S to block Petidyl transferase and prevent peptide bond formation

chloRAMPHEnicol

Ricettsiae
Anaerobes and Atypicals
Meningococci
Pneumococci
H Influenza
Enterobacteriaceae

Sulfamethoxazole

Study These Flashcards

Sulfonamide (O) (broad spectrum) (almost always combo therapy with DHFI) (low solubitiy=Crystalluria)

Competitively inhibits Dihydropteroate Synthase as a structural anolog of PABA to block folate synthesis (needed to synth purines to incorporate into DNA

G+:

Streptococcus
Staphylococcus (CA-MRSA)
Listeria

G-

Enterobacteriaceae
Y. Enterocolitica
E. Coli
Salmonella
Shigella
H. Influenza
Nocardia
Pneumocystis Carinii

Sulfisoxazole

Study These Flashcards

Sulfonamide (O) (broad spectrum) (almost always combo therapy with DHFI) (Highly soluble little renal toxicity)

Competitively inhibits Dihydropteroate Synthase as a structural anolog of PABA to block folate synthesis (needed to synth purines to incorporate into DNA

(COMBO WITH ERYTHROMYCIN FOR OTITIS MEDIA IN KIDS)

G+:

Streptococcus
Staphylococcus (CA-MRSA)
Listeria

G-

Enterobacteriaceae
Y. Enterocolitica
E. Coli
Salmonella
Shigella
H. Influenza
Nocardia
Pneumocystis Carinii

Sulfasalazine

Sulfonamide (O) (broad spectrum) (almost always combo therapy with DHFI) (Poorly absorbable=good for gi and IBD) Competitively inhibits Dihydropteroate Synthase as a structural anolog of PABA to block folate synthesis (needed to synth purines to incorporate into DNA Metabolites have further antibiotic and antiinflammatory 5ASA activity G+: * Streptococcus * Staphylococcus (CA-MRSA) * Listeria G- * Enterobacteriaceae * Y. Enterocolitica * E. Coli * Salmonella * Shigella * H. Influenza * Nocardia * Pneumocystis Carinii

Silver Sulfadiazine

Sulfonamide (TOPICAL) (broad spectrum) (almost always combo therapy with DHFI) (low solubitiy=Crystalluria) Competitively inhibits Dihydropteroate Synthase as a structural anolog of PABA to block folate synthesis (needed to synth purines to incorporate into DNA Inhibits NEARLY ALL BACTERIA AND FUNGI USED IN BURN/SKIN INFECTIONS BUT CAN LEAD TO SUPERINFECTIONS G+: * Streptococcus * Staphylococcus (CA-MRSA) * Listeria G- * Enterobacteriaceae * Y. Enterocolitica * E. Coli * Salmonella * Shigella * H. Influenza * Nocardia * Pneumocystis Carinii

Trimethoprim

Dihydrofolate Reductase Inhibitor Competitive inhibitor of dihydrofolate reductase much stronger for bacterial than human Concentrates in acidic fluid like the prostate and vagina CAN BE USED ALONE IN UTI AND PROSTATE INFECTIONS BUT USUALLY PAIRED WITH SULFONAMIDES G+: * Streptococcus * Staphylococcus (CA-MRSA) * Listeria G- * Enterobacteriaceae * Y. Enterocolitica * E. Coli * Salmonella * Shigella * H. Influenza * Nocardia * Pneumocystis Carinii

Nalidixic Acid

Quinolone Urinary accumulation only: so only used for UTI

Norfloxicin

G1 Fluoroquinolone (Broad Spectrum) (absorption decreases with multivalent cations) Bactericidal: inhibits DNA topoisomerase II (DNA Gyrase) and Topo IV (seperates circular chromosomes after DNA replication decatenation-fluoros block the religation) , thus damaging DNA Urinary accumulation only so only used for UTI G+: * G-: * Atypicals: * Mycobacteria: *

Ciprofloxacin

G2 Fluoroquinolone

Ofloxacin

G2 Fluoroquinolone

Levofloxacin

G3 Fluoroquinolone

Moxifloxacin

G3 Fluoroquinolone (Biliary)

Gemifloxacin

G3 Fluoroquinolone

Quinupristin-Dalfopristin

Protein Synthesis inhibitor 50S Binding (P) (Biliary)

Linezolid

23S Binding Protein Synthesis inhibitor (O,P)

Daptomycin

Lipo-Peptide (P)

Mupirocin

Mupirocin (T)

Isoniazid

TB Drug First Line CWSI (O)

Ethambutol

TB Drug First Line CWSI (O)

Rifampin

Rifamycin TB First Line Drug (O)

Rifabutin

Rifamycin TB First Line Drug (O)

Rifapentine

Rifamycin TB First Line Drug (O)

Pyrazinamide

TB First Line Drug (O)

TB Second Line Drugs

Aminoglycosides: Streptomycin, Amikacin, Kanamycin, capreomycin Fluoroquinolines: Moxi, Levo, Cipro, Gatifloxacin CWSI: Ethionamide, cycloserine Sulfonamide: PAS

Capreomycin

Aminoglycoside TB 2nd line (IM)

Ethionamide

CWSI TB 2nd line (O)

PAS

inhibits acetylation of INH

Leprosy Drugs

Sulfonamide: Dapsone (O) Clofazimine (O) Thalidomide (O)

Thalidomide

(O)

First Line TB Drugs

(O) CWSI: isoniazid, ethambutol Rifamycins: Rifampin, Rifabutin, Rifapentine Pyrazinamide

Spectrums Flashcards

(51 cards)