spironolactone

Question 1

Mechanism of action

Answer 1

aldosterone antagonist

Question 2

Where in the renal tubule does it act?

Answer 2

Cortical collecting duct

Question 3

Indications for spironolactone

Answer 3

ascites (large doses, 100-200mg)
hypertension: ‘step 4’
heart failure
nephrotic syndrome
Conn’s syndrome

Question 4

Common side effects of aldosterone antagonists

Answer 4

hyperkalaemia
gynaecomastia: less common with eplerenone

Question 5

Addition of low dose spironolactone reduces all cause mortality in heart failure. TRUE/FALSE?

Answer 5

TRUE