1
Q
Names 2 types of statins
A
Atorvastatin and Simavastatin
2
Q
What are statins used for
A
To lower cholesterol
-Prevent adverse cardiovascular event
3
Q
What is the MOA of statins
A
They work on the HMG- COA to reduce the production of LDL. This lows the compensatory mechanism to kick in and this allows increase in uptake of LDL from the blood by hepatocytes, this then reduces LDH
4
Q
List Statin side effects
A
Headaches
Muscle pain
GI upset
Rhadomylosis
Raised Liver enzymes
5
Q
Contradiction
A
Patient on simavastatin and Atorvastatin should not take grapefruit
Applied Pharmacological
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