Steps: Rolling

Question 1

? on surface of ?bind to ? expressed on ?

Answer 1

Adhesion receptors on surface of circulating leukocytes bind to adhesion proteins expressed on endothelial cells

Question 2

? and ? expressed on surface of endothelium

Answer 2

P-selectin and E-selectin expressed on surface of endothelium

Question 3

? and ?expressed on leukocytes

Answer 3

Integrins and glycoproteins expressed on leukocytes

Question 4

Leukocytes ? along surface of ?

Answer 4

Leukocytes roll slowly along surface of blood vessel wall

Question 5

Why do leukocytes roll along blood vessel wall?

Answer 5

Low affinity interactions
Blood flow promotes rolling