Deplete
to (over)use over time (usu. resources)
Desolate
bare, barren, empty
Devise
to come up with (a plan)
Dilemma
a problem, usually requiring a choice between two options
Diligence
conscientiousness; the quality of being committed to a task
Diminish
to become smaller in scope or degree
Dire
hopeless and dangerous or fearful
Discord
disagreement
Disdain
a lack of respect and strong dislike (toward something or someone)
Dismay
hopelessness, stress, or consternation