Succinylcholine

Question 1

SUCCINYLCHOLINE

Pharmacology & Actions

Answer 1

• Depolarizing neuromuscular blocker
• Acts on motor end plate receptors, producing depolarization or fasciculations, and inhibiting subsequent neuromuscular transmission for the duration of the medication (short acting)
• Muscles are unable to be stimulated by acetylcholine

Question 2

SUCCINYLCHOLINE

Indications

Answer 2

• Induction of paralysis to facilitate endotracheal intubation

Question 3

SUCCINYLCHOLINE

Absolute Contraindications

Answer 3

• Malignant hyperthermia (may result in irreversible trismus)
• Known or suspected hyperkalemia
• Penetrating eye injury (increases intraocular pressure)
• Inability to control the airway and/or support ventilations
• Paraplegia/quadriplegia
• Musculoskeletal disorders such as muscular dystrophy, spinal muscular atrophy
• Prolonged immobilization
• Stroke w/ residual motor dysfunction
• Succinylcholine allergy

Question 4

SUCCINYLCHOLINE

Precautions & Side Effects

Answer 4

• Use with caution in patients with anticipated difficult airway
• Has no effect on consciousness - sedatives should be used in conjunction with succinylcholine administration

Question 5

SUCCINYLCHOLINE

Administration

Answer 5

• IV/IO
• Onset: 30-60sec
• Peak Effect: 1-3min
• Duration: 7-10min