Drug Cards > Sufentanil > Flashcards

Sufentanil Flashcards

Please note that the drug card information is for Educational Use ONLY, and the source is from Carrie Bowman's glossary of drug cards permitted by use of Georgetown NAP students. No permission is given to use these cards for anything other than as a study resource for our program. (37 cards)

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1
Q

What is the trade name of Sufentanil?

A

Sufenta

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2
Q

What is the drug class of Sufentanil?

A

phenylpiperidine opioid agonist

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3
Q

What are the uses of Sufentanil?

A
  • analgesic adjunct in maintenance of balanced anesthesia
  • can be used as primary anesthetic agent for induction and maintenance
  • can be used in management of chronic severe pain with PCP or transdermal patches
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4
Q

What is the MOA of sufentanil?

A

binds to opioid receptors particularly the mu receptors, throughout the central and peripheral nervous sytem

  • produces dose related attenuation of catecholamine release, especially NE
  • increase of pain threshold, alteration of pain perception, and inhibition of ascending pathways
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5
Q

How is Sufentanil metabolized?

A

Liver and small intestine: major sites of biotransformation

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6
Q

What compartment model describes the distribution of Sufentanil?

A

3 compartment model– highly lipid soluble

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7
Q

What is the potency of Sufentanil as compared to Fentanyl?

A

5 - 10 times more potent than Fentanyl

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8
Q

What is the onset of action of Sufentanil?

A

1 - 3 minutes

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9
Q

What is the elimination 1/2 life of Sufentanil?

A

164 minutes in adults; approximately 80% of the dose administered is excreted within 24hrs, and 2% eliminated unchanged

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10
Q

Is Sufentanil protein bound?

A

approx 93% protein bound

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11
Q

What is the Vd of Sufentanil?

A

2.86 L/kg

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12
Q

What are the CV side effects of Sufentanil?

A
  • Hypotension
  • Bradycardia
  • Arrhythmia
  • Tachycardia
  • Cardiac Arrest
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13
Q

What is the respiratory effects of Sufentanil?

A

Respiratory depression
Apnea
Bronchoconspasm

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14
Q

What are the Skeletal muscle effects of Sufentanil?

A

Chest Wall rigidity

Skeletal muscle rigidity of neck and extremeties

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15
Q

What are the CNS effects of Sufentanil?

A

Confusion
Somnolence
Chills

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16
Q

What are the Dermatological effects of Sufentanil?

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A

Pruritis

Erythema

17
Q

What are the GI side effects of Sufentanil?

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A

Constipation
N/V
Biliary Spasm

18
Q

What are the GU side effects of Sufentanil?

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A

Urinary Retention

19
Q

What are the contraindications to the use of Sufentanil?

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A
  • hypersensitivity
  • severe asthma
  • paralytic ileus
  • use caution in pts with resp disease
20
Q

What drugs increase the levels/effects of sufentanil?

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A

CYP3A4 inhibitors:

  • Azole antifungals
  • Nefazodone
  • Nicardipine
  • Propofol
  • Protease inhibitors
  • Quinidine
  • Verapamil
21
Q

What drugs enhance the magnitude and duration of CNS and CV effects when administered with Sufentanil?

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A
  • Barbiturates
  • Tranquilizers
  • Other opioids
  • GAs
  • CNS depressants
22
Q

How should dosing of Sufentanil be planned?

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A

according to ideal body weight, physical status, underlying pathological conditions, use of other drugs, and type of surgical procedure and anesthesia

23
Q

When should you reduce the dose of Sufentanil?

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A

elderly, debilitated, and neonates

24
Q

What is the analgesia bolus dose of Sufentanil?

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A

0.1 - 1 mcg/kg

25
What is the induction/maintenance dose of Sufentanil for minor procedures?
1 - 2 mcg/kg (balanced technique)
26
What is the Epidural dose of Sufentanil?
10 - 15mcg
27
What is sufentanil an analogue of?
fentanyl
28
_____ x as lipid soluble as Fentanyl
2
29
Only _____% is un-ionized
20%
30
What is Fentanyl's metabolite? is it active?
- desmethylsufentanil | - weakly active
31
_______x more potent than fentanyl
10
32
_______ x more potent than morphine
1,000
33
What is the clinical significance of Sufentanil?
- used as adjunct for surgery and induction - compared to morphine and fentanyl produces quicker induction earlier emergence and earlier extubation - used as infusion for outpatient surgery
34
What is the loading dose of Sufentanil?
0.25--2 mcg/kg
35
What is the IV dose of Sufentanil?
0.1 - 0.3 mcg/kg (per dr e)
36
What is the infusion rate of Sufentanil?
0.0015 - 0.01 mcg/kg/min (per Dr. E)
37
What is the maintenance infusion rate of Sufentanil?
0.5 - 1.5 mcg/kg/hr
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